创伤性脊髓损伤病人的固体胃排空及吗丁啉的治疗观察

首都医科大学学报 ›› 1992, Vol. 13 ›› Issue (4): 277-281.

创伤性脊髓损伤病人的固体胃排空及吗丁啉的治疗观察

曹静宜¹, 王兰¹, 常永顺¹, 王继琛¹, 柯美云²

1. 中国康复研究中心;2. 北京协和医院内科胃肠组

收稿日期:1991-06-18 修回日期:1900-01-01 出版日期:1992-10-15 发布日期:1992-10-15

Gastric Emptying of Solids and Analysis of Therapeutic Efficacy of Domperidone in Traumatic Spinal Cord Injury

Cao Jingyi¹, Wang Lan¹, Chang Yongshun¹, Wang Jichen¹, Ke Meiyun²

1. The China Rehabilitation Research Centre;2. Department of Internal Medicine, Beijing PUMC Hospital

Received:1991-06-18 Revised:1900-01-01 Online:1992-10-15 Published:1992-10-15

摘要/Abstract

摘要： 观察了完全性脊髓损伤病人16例(高位6例、低位10例)的固体胃排空情况,及吗丁啉对延迟胃排空的疗效。发现高位脊髓损伤组(HSCI)餐后3.5及5 h胃排空(GE)明显延迟(P<0.001),低位脊髓损伤组(LSCI)无明显延迟(P=0.053),凡GE延迟者,胃窦的运动减弱、减慢。口服吗丁啉后GE明显改善(P<0.05)。

关键词: 高位脊髓损伤, 低位脊髓损伤, 胃排空, 吗丁啉

Abstract: The aim of this study was to investigate the gastric emptying (GE)of solids in patients with complete spinal cord injury(SCI) and to observe the therapeutic efficacy of DOMPERI-DONE (DOM) on delayed GE.Sixteen patients (6 high-cord, 10 low-cord) and 10 heslthy controls were studied.Radiopaque markers for studying GE were used, the markers retained in the stomach were counted and antral contractions were observed as well.Five patients with delayed GE took DOM 20 mg T.I.D.for 1 week, then the GE repeated.The GE was markedly delayed at 3.5 and 5 h postprandially in high-cord group compared with controls (P<0.001) but no significant difference was seen in low-cord group at 5 h postprandially (P=0.053).All the patients with delayde GE had decreased antral motility.After the oral administration of DOM the GE was greatly improved (P<0.05).We conclude that high-cord patients(above T₅) have delayed GE of solids, partial low-cord (below T₁₀)delay also, and DOM accelerates the GE.

Key words: high-spinsl cord injury (HSCI), low-spinal cord injury(LSCI), gastric emptying, domperidone

中图分类号:

R681.5

曹静宜;王兰;常永顺;王继琛;柯美云. 创伤性脊髓损伤病人的固体胃排空及吗丁啉的治疗观察[J]. 首都医科大学学报, 1992, 13(4): 277-281.

Cao Jingyi;Wang Lan;Chang Yongshun;Wang Jichen;Ke Meiyun. Gastric Emptying of Solids and Analysis of Therapeutic Efficacy of Domperidone in Traumatic Spinal Cord Injury[J]. Journal of Capital Medical University, 1992, 13(4): 277-281.

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