首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (1): 8-15.

• 论著 • 上一篇    下一篇

鼠胚胎脑组织移植物血管构筑的研究

刘玉军, 张国风, 蔡青, 王元身, 鲁强, 焦守恕   

  1. 首都医学院北京神经科学研究所
  • 收稿日期:1991-12-02 修回日期:1900-01-01 出版日期:1993-01-15 发布日期:1993-01-15

The Study on Vessel Construction of Fetal Rat Brain Grafts

Liu Yujun, Zhang Guofeng, Cai Qin, Wang Yuansheng, Lu Qiang, Jiao Shoushu   

  1. Beijing Institute for Neuroscience, Capital Institute of Medicine
  • Received:1991-12-02 Revised:1900-01-01 Online:1993-01-15 Published:1993-01-15

摘要: 通过观察胚胎脑组织移植后移植物内血管生长时相、血管构筑和血液供应与移植物存活的关系,研究移植物内血管重建的规律。发现移植后5~15 d 移植物内血管密度逐渐增加;15~30 d 左右血管密度最高,血管平均直径也最大;30 d 以后血管密度有所降低,平均直径也下降。移植物内血管从外周向中心区方向生长,但血管分布常不均匀,在多数情况下血管密度较高区域内神经细胞存活数量较多。移植物内血管管径较正常脑区粗大.但血管密度明显低于对侧相应部位正常脑区。在移植物相邻脑区或对照组损伤部位相邻脑区中都有明显的血管增生、血管管径增粗,并且增生的血管明显地趋向于移植区或损伤区生长。

关键词: 大鼠, 神经移植, 血管构筑

Abstract: The pattern of vascular reconstruction of graft was studied by observing the time-de-pendent growth of vessel,vascular construction and the relationship between blood supply and graft survival.The benzidin-stein techique was employed to present vessel and result was analysed with electron computer imaging analysis.The vascular density increased gradually from 5 to 10 days after transplantation,and it appeared the densest from 15 to 30 days,with the mean diameter of vessles becoming the thickest too.Both the vascular density and mean diamater got lower beyond 30 days survival.The vessels grew from periphery to the center, but it's unevenly distributed.In most cases,vascular deusity was high in areas with more survived neural cells.The vessels within grafts were thicker in diameter,but less in density than those within homologous normal area of brain.Within the areas neithbouring to grafts or demaged sites of the control group,vessels regenerated evidently and vescular diameter in-creased.They grew in the direction toward graft or lesioned area.

Key words: rat, nerve, transplantation, blood vessel regeneration

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