首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (2): 120-123.

• 论著 • 上一篇    下一篇

脑内不同部位颈交感神经节移植后大鼠旋转行为改善的观察

杜建新1, 板苍辙2, 丁育基1   

  1. 1. 首都医学院宣武医院神经外科;2. 日本和歌山医大脑神经外科
  • 收稿日期:1991-12-09 修回日期:1900-01-01 出版日期:1993-04-15 发布日期:1993-04-15

Recovery of Rotational Behavior After SCG Transplantaton in 6-OHDA-Induced Parkinson Model Rat

Du Jianxin1, Itakura T2, Ding Yuji1   

  1. 1. Department of Neurosurgery, Xuanwu Hospital, Capital Institute of Medicine;2. Department of Neurosurgery, Wakayama Hospital, Japan
  • Received:1991-12-09 Revised:1900-01-01 Online:1993-04-15 Published:1993-04-15

摘要: 大鼠脑内黑质注入六羟基多巴(6-OHDA).使其成为帕金森病的模型后.将大鼠自体颈交感神经节移植入脑内不同部位,以观察其对模型的旋转行为的纠正程度.我们选择了两处移植靶点(尾状核和壳核)进行实验.结果表明颈交感神经节在两处移植点具有相似的效应,均可使模型鼠在注入阿仆吗啡后的单方向旋转强度下降约50%。儿茶酚胺组织荧光检查显示被移植的神经节成活良好.

关键词: 上颈交感神经节, 移植, 尾状核, 壳核

Abstract: Autologous superior cervical ganglion transplantation was performed into the different places in rat’s brain where the nigro-striatal dopamine system was unilaterally destoried by 6-OHDA injection.Two different locations for grafts were tested,namely the caudate and the putament.Almost the same effect on recovering ratationlal behaviour induced by apo-morphine was acheived in both groups.The intensity of ratation was about 50 per cent de-crease afer grafting.Catecholamine fluroscence histoehemical study showed good survival of grafted tissue.

Key words: transplantation, superior cervical ganglion, putament, caudate

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