苦参体外抗贾第虫药物作用的初步观察

首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (2): 99-101.

苦参体外抗贾第虫药物作用的初步观察

卢思奇¹, 庞苏红¹, 王凤芸¹, 赵玉英², 楼之岑²

1. 首都医学院寄生虫学教研室;2. 北京医科大学药学院植化室

收稿日期:1992-01-20 修回日期:1900-01-01 出版日期:1993-04-15 发布日期:1993-04-15

A Preliminary Observation on the Activity of the Sophora Feavecens Ait Against Giardia Lamblia in Vitro

Lu Siqi¹, Pang Suhong¹, Wang Fengyun¹, Zhao Yuying², Lou Zhicen²

1. Department of Parasitology, Capital Institute of Medicine;2. Beijing Medical University, School of Pharmacology

Received:1992-01-20 Revised:1900-01-01 Online:1993-04-15 Published:1993-04-15

摘要/Abstract

摘要： 对从苦参生药中制备的3种制剂——苦参总黄酮、苦参乙醇提取物和苦参总生物碱的体外抗贾第虫药物作用做了观察.在与贾第虫滋养体培养72h 后,它们的致死浓度分别为2.5、0.5和5mg/ml,即100%虫体死亡;当其浓度分别为0.5、0.25和2.5mg/ml 时,虫体生长受到抑制;浓度分别在0.05、0.05和0.5mg/ml 时,虫体生长不受影响。与甲硝哒唑相比,它们的用量虽较大,但均有杀灭虫体的作用。本实验的结果支持临床上应用苦参治疗贾第虫病。

关键词: 贾第虫, 苦参, 总黄酮, 乙醇提取物, 总生物碱

Abstract: Three preparations,alkaloid,ethanol extract and flavonoid,prepared from the Sophora feavecens Ait (Sophora angustifolia)were evaluated in vitro for antigiardia effect.The lethal concentrations of the 3 agents were 2.5mg/ml,0.5mg/ml and 5mg/ml respectively on the 72nd hour after cultivated with G.lamblia trophozoites.When their concentrations were 0.5 mg/ml,0.25mg/ml and 2.5mg/ml respectively,the growth of the trophozoites was inhi-bited.No antigiardia effect could be found as their concentrations were 0.05 mg/ml,0.05 mg/ml and 0.5mg/ml respectively.In comparison of the effects of the agents with that of mitronidazole,a similar antigiardia effect was observed.The present results support the clini-cal therapy for giardiasis by using the herb Sophora feavecens Ait.

Key words: Giardia lamblia, Sophora feaveeens Ait, flavonoid, ethanol extract, alkaloid

中图分类号:

R381.14

卢思奇;庞苏红;王凤芸;赵玉英;楼之岑. 苦参体外抗贾第虫药物作用的初步观察[J]. 首都医科大学学报, 1993, 14(2): 99-101.

Lu Siqi;Pang Suhong;Wang Fengyun;Zhao Yuying;Lou Zhicen. A Preliminary Observation on the Activity of the Sophora Feavecens Ait Against Giardia Lamblia in Vitro[J]. Journal of Capital Medical University, 1993, 14(2): 99-101.

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