首都医科大学学报 ›› 1993, Vol. 14 ›› Issue (4): 284-286.

• 论著 • 上一篇    下一篇

老年男性冠心病患者性激素失衡及睾酮制剂的调节作用

吴赛珠, 翁心植   

  1. 首都医学院附属北京红十字朝阳医院内科
  • 收稿日期:1992-06-03 修回日期:1900-01-01 出版日期:1993-10-15 发布日期:1993-10-15

Disorder of Sex Hormones and Regulation of a Androgenic Preparation in Elderly Men with Coronary Heart Disease

Wu Saizhu, Wong Xinzhi   

  1. Beijing Red-Cross Chaoyang Hospital, Capital Institute of Medicine
  • Received:1992-06-03 Revised:1900-01-01 Online:1993-10-15 Published:1993-10-15

摘要: 采用随机、交叉试验法,给62例老年男性冠心病(CHD)患者口服新一代睾酮制剂andriol.结果表明,老年男性CHD患者存在血清性激素(SH)失衡,即血清睾酮(T)水平较健康组降低,雌二醇(E2)水平及E2/T比值较健康组升高(P均<0.001);andriol可使患者的SH失衡得以改善,即血清T水平明显上升(P<0.001),E2水平无显著变化(P>0.05),E2/T比值下降(P<0.05).而对照组无此作用.服用andriol未见明显副作用.

关键词: 冠心病, 睾酮, 雌二醇

Abstract: We conducted a random crossover study on the effects of a new androgenic preparation “andriol”in 62 elderly men with coronary heart disease(CHD).Our results showed that serum estradial(E2)level and estradial/testosterone(E2/T)ratio were significantly elevated and serum T level was significantly reduced(all P<0.001)in CHD patients,when com-pared with those in healthy controls,indicating that there was disorder of sex hormones (SH)in elderly men with CHD.After administration of andriol,the disorder of SH in CHD patients was improved,that is,serum T level was increased significantly(P<0.001),E2 le-vel did not change significantly(P>0.05)and E2/T ratio was reduced(P<0.05).There was no significant change in the control group.No obvious side effect was found in those who took andriol.

Key words: coronary heart disease, testosterone, estradial

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