MPS对环磷酰胺作用的小鼠白细胞的影响

首都医科大学学报 ›› 1994, Vol. 15 ›› Issue (2): 103-105.

MPS对环磷酰胺作用的小鼠白细胞的影响

沈海中, 刁东梅, 赵文明, 陈仁

首都医学院微生物学教研室

收稿日期:1993-06-01 修回日期:1900-01-01 出版日期:1994-04-15 发布日期:1994-04-15

Effects of Mycobacterial Polysaccharides on the Mice's Leucocytopenia Caused by Cyclophosphamide

Shen Haizhong, Diao Dongmei, Zhao Wenming, Chen Ren

Department of Microbiology, Capital Institute of Medicine

Received:1993-06-01 Revised:1900-01-01 Online:1994-04-15 Published:1994-04-15

摘要/Abstract

摘要： 对分枝杆菌多糖(Mycobacterial polysaccharides,MPS)对环磷酰胺(cyclophosphamide,CP)所致白细胞减少小鼠的影响进行了实验观察.小鼠腹腔注射CP,制作白细胞减少动物模型.实验组在给予CP的翌日,注射MPS(5或25μg/只·d^-1),连续4d.隔日计数白细胞.与对照组比较,实验组白细胞数下降较少,回升迅速.结果提示MPS有抑制CP所致白细胞降低及促进白细胞回升的作用.

关键词: 白细胞减少, 分枝杆菌多糖, 白细胞回升

Abstract: We observed that Mycobacterial polysaccharides(MPS)had effects on the mice's leucocytopenia caused by cyclophosphamide(CP). We injected CP to the mice's abdominal cavities to make a leucocytopenia model. In experimental groups,the second day after the injection with CP,the mice were given MPS with 5 or 25 μg/mouse.d^-1 for four days and the leukocytes were examined every other day.In comparison with the control groups,the experimental mice had a lower rate of leucocytopenia and recovered rapidly from it. The data reveals that MPS have functions on inhibiting the mice's leucocytopenia caused by CP and on promoting the recovery of leukocyte.

Key words: leucocytopenia, Mycobacterial polysaccharides, recovery of leukocyte

中图分类号:

R392.1

沈海中;刁东梅;赵文明;陈仁. MPS对环磷酰胺作用的小鼠白细胞的影响[J]. 首都医科大学学报, 1994, 15(2): 103-105.

Shen Haizhong;Diao Dongmei;Zhao Wenming;Chen Ren. Effects of Mycobacterial Polysaccharides on the Mice's Leucocytopenia Caused by Cyclophosphamide[J]. Journal of Capital Medical University, 1994, 15(2): 103-105.

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