对液化石油气燃烧产物接触者尿致突变性的研究

首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (1): 20-23.

对液化石油气燃烧产物接触者尿致突变性的研究

尹学钧¹, 肖中新¹, 褚金花¹, 孔祥环¹, 王虹¹, 刘君卓²

1. 首都医科大学环境卫生学教研室;2. 北京医科大学环境卫生学教研室

收稿日期:1995-04-19 修回日期:1900-01-01 出版日期:1996-01-15 发布日期:1996-01-15

Mutagenicity of Urine from Humans Exposed to LPG Combustion Products

Yin Xuejun¹, Xiao Zhongxin¹, Chu Jinhua¹, Kong Xianghuan¹, Wang Hong¹, Liu Junzhuo²

1. Department of Environmental Health, Capital University of Medical Sciences;2. Department of Environmental Health, Beijing Medical University

Received:1995-04-19 Revised:1900-01-01 Online:1996-01-15 Published:1996-01-15

摘要/Abstract

摘要： 应用鼠伤寒沙门菌株TA98及其新的衍生菌株YG1021和YG1024检测了液化石油气(LPG)燃烧产物接触者尿的致突变性。吉果表明,在有大鼠S₉已β-葡萄糖醛酸酶存在时,尿样显示较强的致突变性。尿样对YG1024的致突变性明显高于TA98,而对YG1021的致突变性与TA98相近。提示LPG燃烧产物接触者尿中致突变物主要是以葡萄糖醛酸贰结合状态存在的芳香胺类物质。同时也证明YG1024在检测该尿样的致突变性上比TA98更为敏感。

关键词: 液化石油气, 燃烧产物, 尿致突变性, Ames试验

Abstract: The mutagenicity of urine from humans exposed to the combustion products of liquefied petroleum gas(LPG)was detected with Salmonella typhimurium TA98 and its new derivatives YG1021 and YG1024.The samples showed evident mutagenicity in thepresence of both rat liver S₉ and β-glucuronidase.The mutagenicity in YG1024 was significantly higher than that in TA98.The mutagenicity in YG1021,however,was similar to TA98 under the same conditions.This suggests that the mutagenic compounds presented in the urine samples are mainly aromatic amino compounds as glucuronide conjugates.The results also demonstrate that YG1024 is more sensitive than TA98 in detecting the mutagenicity of these samples.

Key words: liquefied petroleum gas, combustion product, urine mutagenicity, Ames test

中图分类号:

R122

尹学钧;肖中新;褚金花;孔祥环;王虹;刘君卓. 对液化石油气燃烧产物接触者尿致突变性的研究[J]. 首都医科大学学报, 1996, 17(1): 20-23.

Yin Xuejun;Xiao Zhongxin;Chu Jinhua;Kong Xianghuan;Wang Hong;Liu Junzhuo. Mutagenicity of Urine from Humans Exposed to LPG Combustion Products[J]. Journal of Capital Medical University, 1996, 17(1): 20-23.

[1]	孔祥环;尹学钧;王虹;肖中新;褚金花;李向红. TA98及其衍生菌株检测大气颗粒物致突变作用的比较研究[J]. 首都医科大学学报, 1996, 17(4): 263-266.
[2]	孔祥环;蒋保季;王惠琴;尹学钧;唐玉萍;马忠杰;沈家琴;张宏伟;肖中新. 发酵培育冬虫夏草毒理研究　Ⅱ．致突变性研究[J]. 首都医科大学学报, 1995, 16(4): 256-258.
[3]	尹学钧;李永顺;孔祥环;刘君卓. 液化石油气燃烧颗粒物对小鼠骨髓细胞微核率的影响[J]. 首都医科大学学报, 1994, 15(3): 191-193.