孕酮受体在小鼠子宫内的分布及其与胚泡植入的关系

首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (1): 1-3.

孕酮受体在小鼠子宫内的分布及其与胚泡植入的关系

诸定寿, 梁元晶, 许晴, 翁静, 史小林, 路欣

首都医科大学生殖医学研究室

收稿日期:1996-02-09 修回日期:1900-01-01 出版日期:1997-01-15 发布日期:1997-01-15

Distribution of Progesterone Receptorin Uterus of Mouse and Its Relation with Blastula Implantation

Zhu Dingshou, Liang Yuanjing, Xu Qing, Weng Jing, Shi Xiaolin, Lu Xin

Center of Reproductive Medicine, Capital University of Medical Sciences

Received:1996-02-09 Revised:1900-01-01 Online:1997-01-15 Published:1997-01-15

摘要/Abstract

摘要： 用LSAB法、兔抗人孕酮受体抗体显示子宫中孕酮受体的变化。结果:孕酮受体位于子宫内膜上皮细胞、基质细胞和肌层平滑肌细胞的细胞核内,细胞质未见阳性物质。动情间期子宫肌层和内膜上皮及基质细胞呈较弱阳性反应,两层无明显差别。动情期表面上皮和腺上皮反应增强,而肌层仍保持原水平。提示孕酮受体在子宫为胚泡着床做好准备的过程中起重要作用。孕4～6d子宫基质(蜕膜)细胞成为子宫中孕酮受体含量最丰富的组织,提示孕酮受体在植入的胚泡与母体之间的信息交换与免疫保护方面有重要意义。

关键词: 孕酮受体, 子宫内膜细胞, 胚泡植入, 免疫细胞化学

Abstract: Immunocytochemical LSAB methods were used to show changes of progesterone receptor in endometrium.We found that progesterone receptor located in the nucleus of uterine endometrium cell,stroma cell and smooth muscle cell,but not in their cytoplasma.During disestrus the uterine muscular cell and endometrium cell showed positive reaction (1+).There was no difference between them.In estrus,the endometrial cell and gland epithelium showed comparatively strongly positive result(1.5+),but muscular cell remained the same.The results indicated that progesterone receptor play an important role in the preparation of blastula implantation.

Key words: progesterone receptor, blastula implantation, endometrium cell, immunocytochemistry

中图分类号:

R492.6

诸定寿;梁元晶;许晴;翁静;史小林;路欣. 孕酮受体在小鼠子宫内的分布及其与胚泡植入的关系[J]. 首都医科大学学报, 1997, 18(1): 1-3.

Zhu Dingshou;Liang Yuanjing;Xu Qing;Weng Jing;Shi Xiaolin;Lu Xin. Distribution of Progesterone Receptorin Uterus of Mouse and Its Relation with Blastula Implantation[J]. Journal of Capital Medical University, 1997, 18(1): 1-3.

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