首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (1): 37-40.

• 论著 • 上一篇    下一篇

分枝杆菌多糖治疗支气管哮喘的临床研究

陆吉贤1, 王健军1, 刘复强1, 叶志明1, 张进友2, 王津津2, 陈海伦3, 陈仁3   

  1. 1. 首都医科大学附属北京同仁医院内科;2. 首都医科大学附属北京同仁医院中心实验室;3. 首都医科大学微生物学教研室
  • 收稿日期:1996-01-12 修回日期:1900-01-01 出版日期:1997-01-15 发布日期:1997-01-15

A Clinic Study of Mycobacterial Polysaccharides on Treatment of Bronchial Asthma

Lu Jixian1, Wang Jianjun1, Liu Fuqiang1, Ye Zhiming1, Zhang Jinyou2, Wang Jinjin2, Chen Hailun3, Chen Ren3   

  1. 1. Department of Internal Medicine, Tongren Hopital, Affiliate of Capital University of Medical Sciences;2. Department of Microbiology, Capital University of Medical Sciences
  • Received:1996-01-12 Revised:1900-01-01 Online:1997-01-15 Published:1997-01-15

摘要: 对52例支气管哮喘发作期患者进行了外周血T细胞亚群、IgG4、IgE、sIL-2R、ACTH及皮质醇的测定。结果显示哮喘发作期IgG4、IgE、sIL-2R及ACTH均显着升高,提示哮喘患者存在细胞免疫及内分泌功能的异常。将分枝杆菌多糖(MPS)用于32例哮喘患者的治疗,结果与20例常规治疗组比较,MPS组CD4+/CD8+比值明显升高,IgG4和sIL-2R显着下降,而皮质醇和ACTH无明显变化。

关键词: 支气管哮喘, IgG4, IgE, sIL-2R, T细胞亚群, 促肾上腺皮质激素, 皮质醇

Abstract: cell subgroup,IgG4,IgE,sIL-2R,ACTH and cortisol in 52 patients peripheral blood with bronchial asthma onset phase,as well as 50 controls were measured.The levels of IgG4,IgE,sIL-2R and ACTH in asthma patients were significantly higher compared to those of controls.The results suggest abnormality of cell immunity and endocrinic function in asthma onset phase.52 patients were divided into 2 groups,32 were treated with MPS,20 with regular therapy.The values of CD4+/ CD8+ in 32 patients after treatment with MPS greatly increased and the levels of IgG4,sIL-2R decreased,but ACTH,cortisol did not change.

Key words: bronchial asthma, IgG4, IgE, sIL2R, T cell subgroup, ACTH, cortisol

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