家族性氨基糖甙类抗生素耳中毒易感性与 HLA 相关性的研究

首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (1): 59-63.

家族性氨基糖甙类抗生素耳中毒易感性与 HLA 相关性的研究

诸小侬¹, 刘炜¹, 冯彦¹, 范尔钟¹, 廉能静¹, 夏文茹¹, 赵小燕¹, 王鸿¹, 孔繁华², 刘东林², 陈仁³

1. 北京市耳鼻咽喉科研究所;2. 解放军三○七医院;3. 首都医科大学

收稿日期:1996-01-10 修回日期:1900-01-01 出版日期:1997-01-15 发布日期:1997-01-15

Susceptibility of Genetic Aminoglycoside-induced Hearing Loss

Zhu Xiaonong¹, Liu Wei¹, Fen Yan¹, Fan Erzhong¹, Lian Nengjing¹, Xia Wenru¹, Zhao Xiaoyan¹, Wang Hong¹, Kong Fanhua², Liu Donglin², Chen Ren³

1. Beijing ENT Institule;2. 307 Hospital of PRC;3. Capital University of Medical Scienses

Received:1996-01-10 Revised:1900-01-01 Online:1997-01-15 Published:1997-01-15

摘要/Abstract

摘要：

以人类白细胞抗原(HLA)为遗传标志,选用8个随机婚配的氨基糖甙类耳中毒(以下简称耳中毒)家庭,测定其HLA抗原型别,根据分型结果进行连锁分析(Lods法)、单倍型分离分析和患病同胞对的分析。结果表明,家族性耳中毒易感基因很可能与HLA基因连锁,并以显性方式遗传。

关键词: 家族性, 耳中毒, HLA

Abstract:

We notice that the aminoglycoside induced hearing loss often happens with an obviously high familial susceptibility, showing a mother to child genetic phenomenon. To find the immunogenetic mechanism of this disease,we chose 8 affected kindreds, in each of which there was no blood relationship between father and mother, to test the family members'HLA types. The linkage analysis (with Lods Method), haploid analysis and affected sib pairs analysis were done after the typing. The results suggest that the gene(s) which affects the susceptibility of antibiotic induced hearing loss is possibly linked with the HLAgenes and is inherited according to a model of autosomal dominant inheritance.

Key words: genetic, ototoxicity, HLA

中图分类号:

R764.4

诸小侬;刘炜;冯彦;范尔钟;廉能静;夏文茹;赵小燕;王鸿;孔繁华;刘东林;陈仁. 家族性氨基糖甙类抗生素耳中毒易感性与 HLA 相关性的研究[J]. 首都医科大学学报, 1997, 18(1): 59-63.

Zhu Xiaonong;Liu Wei;Fen Yan;Fan Erzhong;Lian Nengjing;Xia Wenru;Zhao Xiaoyan;Wang Hong;Kong Fanhua;Liu Donglin;Chen Ren. Susceptibility of Genetic Aminoglycoside-induced Hearing Loss[J]. Journal of Capital Medical University, 1997, 18(1): 59-63.

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