首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (2): 101-104.

• 论著 • 上一篇    下一篇

Mauthner细胞脊髓EPSP前电位起源分析

张茂先, 虞棻, 张淑华, 李效义, 童学红, 张英才   

  1. 首都医科大学生理学教研室
  • 收稿日期:1996-10-17 修回日期:1900-01-01 出版日期:1997-04-15 发布日期:1997-04-15

Origin of the Spinal pre-EPSP in Mauthner Cell

Zhang Maoxian, Yu Fen, Zhang Shuhua, Li Xiaoyi, Tong Xuehong, Zhang Yingcai   

  1. Department of Physiology, Capital University of Medical Sciences
  • Received:1996-10-17 Revised:1900-01-01 Online:1997-04-15 Published:1997-04-15

摘要: 用单个方波脉冲刺激鲫鱼脊髓,逆向激活M细胞轴突,同时刺激脊髓内的上行传导通路.用玻璃微电极在延髓M细胞胞体进行细胞内记录.结果发现,M细胞逆向动作电位的降支上虽然经常出现错折,但错折与逆向动作电位本身并无必然联系.用阳极阻滞方法显露出来的错折电位呈尖峰状,与后继的低幅度去极化反应联系紧密,不可分离,共同构成一复合EPSP.它比脊髓EPSP的潜伏期短、幅度小、阈值更低,经常与M细胞的轴突同时被激活.将其称为脊髓EPSP前电位,简称前电位.

关键词: Mauthner细胞, 脊髓EPSP, 脊髓EPSP前电位

Abstract: In the Crucion Carp,the axon of the Mauthner cell and,at the same time,the spinal afferent pathway were activated by stimulation of the spinal cord with single rectangular pulse and the evoked responses of the Mauthner cell in the medulla oblongata were intracellularly recorded. The results showed that although spinal stimulation always induced antidromic action potential with a notch on its descending limb, there was no inevitable relation between the notch and the action potential itself. Each of them could be independently induced by suitable stimulation. The spike like notch potential and the successive small depolarizing response were inseparable and made up a compound EPSPwhich was named by us the spinal pre-EPSP(simply pre-EPSP).The pre-EPSPwas also induced by stimulation of the spinal afferents as the spinal EPSP,but with smaller amplitude,shorter latency and lower threshold, so that it was often activated togather with Maxon.

Key words: Mauthner cell, the spinal EPSP, the spinal pre-EPSP

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