首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (3): 222-224.

• 论著 • 上一篇    下一篇

雌性小鼠生殖系统、垂体和大脑中孕酮受体的免疫细胞化学研究

诸定寿, 翁静, 许晴, 史小林, 路欣, 梁元晶   

  1. 首都医科大学生殖医学中心
  • 收稿日期:1996-06-18 修回日期:1900-01-01 出版日期:1997-07-15 发布日期:1997-07-15

Immunocytochemistry of Progesterone Receptors in Reproductive System,Pituitary Gland and Cerebrum of Female Mice

Zhu Dingshou, Weng Jing, Xu Qing, Shi Xiaolin, Lu Xin, Liang Yuanjing   

  1. Reproductive Medicine Center, Capital University of Medical Sciences
  • Received:1996-06-18 Revised:1900-01-01 Online:1997-07-15 Published:1997-07-15

摘要: 应用免疫细胞化学LSAB法和孕酮受体抗体研究了雌性小鼠生殖系统、垂体和大脑中孕酮受体的分布及其与胚泡植入的关系。结果:孕酮受体主要分布于子宫和阴道,输卵管中含量极少。它们均位于细胞核内,胞质为阴性。卵巢、垂体和大脑未见阳性反应细胞。孕酮受体在子宫内膜表面上皮和间质中的含量变化与胚泡植入平行发展。结果提示:子宫内膜在为胚泡植入做准备的过程中与孕酮受体的关系密切。

关键词: 孕酮受体, 小鼠, 生殖系统, 垂体, 大脑, 免疫细胞化学

Abstract: Progesterone receptors in reproductive system (including ovary,fallopian tube,uterus and vagina),pituitary gland and cerebrum of female mice were studied by immunocytochemical LSABmethod in order to show the distribution of receptors and the relationship between the receptors and blastula implantation.Progesterone receptors distributed mainly in uterus and vagina,and only a few in fallopian tube.The receptors were located in nuclei, but not in cytoplasm.No positive reaction could be detected in ovary, pituitary gland and cerebrum.The amount changes of the receptors in the endometrial epithelium and the uterine stroma were consistent with the development of blastula implantation.These data suggest that the progesterone receptors are closely related with the endometrial preparation for blastula implantation.

Key words: progesterone receptor, mouse, reproductive system, pituitary gland, cerebrum, immunocytochemistry

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