实验性脾虚证大鼠胃窦部SP、VIP、CGRP含量的研究

首都医科大学学报 ›› 1998, Vol. 19 ›› Issue (2): 105-108.

实验性脾虚证大鼠胃窦部SP、VIP、CGRP含量的研究

刘素梅¹, 曲瑞瑶¹, 王伟¹, 曾文红¹, 曲柏林¹, 王秀琴², 曾晓蓓², 尚宏伟²

1. 首都医科大学生理学教研室;2. 首都医科大学组织胚胎学教研室

收稿日期:1997-06-23 修回日期:1900-01-01 出版日期:1998-04-15 发布日期:1998-04-15

An Investigation of SP, VIP, CGRP Levels in Gastric Autrum of Experimental Spleen Deficiency Rats

Liu Sumei¹, Qu Ruiyao¹, Wang Wei¹, Zeng Wenhong¹, Qu Bailin¹, Wang Xiuqin², Zeng Xiaobei², Shang Hongwei²

1. Department of Physiology, Capital University of Medical Sciences;2. Department of Histology and Embryology, Capital University of Medical Sciences

Received:1997-06-23 Revised:1900-01-01 Online:1998-04-15 Published:1998-04-15

摘要/Abstract

摘要： 采用放射免疫分析方法(RIA)观察了实验性脾虚证大鼠胃窦部P物质(SP)、血管活性肠肽(VIP)、降钙素基因相关肽(CGRP)含量的变化.结果:脾虚组胃窦部SP、VIP、CGRP免疫活性肽(ir-SP、ir-VIP、ir-CGRP)含量均明显降低,下降百分率为ir-SP>ir-VIP>ir-CGRP.自然恢复组ir-SP含量无明显恢复,ir-VIP、ir-CGRP含量均恢复正常.加味四君子汤治疗组ir-SP含量有一定程度恢复,但与对照组相比仍有显着差异,ir-VIP、ir-CGRP含量均恢复正常.结果提示:脾虚大鼠胃窦部ir-SP、ir-VIP、ir-CGRP含量的改变可能与脾虚证胃动力失调有一定关系,加味四君子汤对大鼠实验性脾虚证胃肠肽分泌异常有一定调理作用.

关键词: P物质, 血管活性肠肽, 降钙素基因相关肽

Abstract: Substance P(SP),vasoactive intestinal peptide(VIP), calcitonin gene related peptide(CGRP)levels in all layers of gastric antrum in experimental spleen deficiency(SD)rats were measured by radioimmunoassys(RIA).The results show that: The ir-SP,ir-VIP,ir-CGRP levels in gastric antrum of SD rats were significantly lower than that of control. The reduced percent is ir-SP>ir-VIP>ir-CGRP. In spontaneous recovery cases, ir-SP level was still less than control, while ir-VIP, ir-CGRP levels recovered. After treated with Sijunzi Tang, ir-SP was slightly improved but still showed significantly difference compared with control. ir-VIP, ir-CGRP were improved to the levels of control group. Changes of SP,VIP, CGRP levels in gastric antrum of SD rats may be closely related to the gastrointestinal motility disorders presented in SD. The Chinese herbs(Sijunzi Tang)currently used have partially therapeutic effect.

Key words: spleen deficiency, substance P(SP), vasoactive intestinal peptide(VIP), calcitonin gene related peptide(CGRP)

中图分类号:

Q482
R333.2

刘素梅;曲瑞瑶;王伟;曾文红;曲柏林;王秀琴;曾晓蓓;尚宏伟. 实验性脾虚证大鼠胃窦部SP、VIP、CGRP含量的研究[J]. 首都医科大学学报, 1998, 19(2): 105-108.

Liu Sumei;Qu Ruiyao;Wang Wei;Zeng Wenhong;Qu Bailin;Wang Xiuqin;Zeng Xiaobei;Shang Hongwei. An Investigation of SP, VIP, CGRP Levels in Gastric Autrum of Experimental Spleen Deficiency Rats[J]. Journal of Capital Medical University, 1998, 19(2): 105-108.

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