慢性缺氧所致肺血管结构改建机制的探讨

首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (1): 28-31.

慢性缺氧所致肺血管结构改建机制的探讨

刘帆¹, 陈瑞芬², 刘国贞², 宋爱利²

1. 首都医科大学附属北京友谊医院实验中心;2. 首都医科大学病理解剖学教研室

收稿日期:1998-09-22 修回日期:1900-01-01 出版日期:1999-01-15 发布日期:2013-10-16

Mechanism of Pulmonary Vascular Structure Remodeling Induced by Chronic Hypoxia

Liu Fan¹, Chen Ruifen², Liu Guozhen², Song Aili²

1. Laboratory Center, Beijing Frendship Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Pathology, Capital University of Medical Sciences

Received:1998-09-22 Revised:1900-01-01 Online:1999-01-15 Published:2013-10-16

摘要/Abstract

摘要：

利用常压缺氧舱建立大鼠肺缺氧模型,通过HE、VG、免疫组化染色及电镜,观察慢性缺氧所致的肺血管结构改建。发现其结构改建主要表现为:①肺动脉外膜胶原纤维增生;②肺外周肌性小动脉中膜增厚;③肺泡内无肌性小动脉肌型化。并对慢性缺氧所致肺血管结构改建的机制进行了探讨。

关键词: 慢性缺氧, 血管改建, 病理变化

Abstract:

Rat was used as the hypoxia model by being kept in the normobaric hypoxia chamber. The lung sections were stained with routine HE, VG and immunohistochemical methods. Some specimens were examined by electromicroscope. Results showed that the remodeling of the pulmonary vascular structure under chronic hypoxia included: ① significant proliferation of the adventitial collagen fiber in pulmonary arteries. ②hypertrophy of the medial coat of peripheral muscular arterioles and ③ muscularization of the nonvascular arterioles in the alveolar septa.

Key words: chronic hypoxia, remodeling of vascular structure, pathologic changes

中图分类号:

R365.56

刘帆;陈瑞芬;刘国贞;宋爱利. 慢性缺氧所致肺血管结构改建机制的探讨[J]. 首都医科大学学报, 1999, 20(1): 28-31.

Liu Fan;Chen Ruifen;Liu Guozhen;Song Aili. Mechanism of Pulmonary Vascular Structure Remodeling Induced by Chronic Hypoxia[J]. Journal of Capital Medical University, 1999, 20(1): 28-31.

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