国产和进口rHuEPO治疗长期血透慢性肾衰竭贫血患者的疗效比较

首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (2): 110-112.

国产和进口rHuEPO治疗长期血透慢性肾衰竭贫血患者的疗效比较

孙倩美, 邓敏, 彭立人

首都医科大学附属北京红十字朝阳医院肾内科

收稿日期:1999-01-20 修回日期:1900-01-01 出版日期:1999-04-15 发布日期:1999-04-15

Comparison of the Effect of Homemade rHuEPO and Imported rHuEPO on Treating Patients with Anemia in Chronic Renal Failure Udergoing Long-term Hemodialysis

Sun Qianmei, Deng Min, Peng Liren

Department of Renal, Beijing Red Gross Chaoyang Hospital, Affiliate of Capital University of Medical Sciences

Received:1999-01-20 Revised:1900-01-01 Online:1999-04-15 Published:1999-04-15

摘要/Abstract

摘要： 研究和比较国产与进口基因重组人红细胞生成素(rHuEPO)对长期血液透析(HD)慢性肾衰竭(CRF)贫血患者的影响。将60例长期血透慢性肾衰竭贫血病人随机分成2组,分别应用国产rHuEPO(益比奥)、进口rHuEPO(生血素)100μg/(kg·周),均分3次治疗。2组患者在治疗第2周网织红细胞(RRBC)均显着上升,治疗12周内血细胞比容(HCT)均达到0.30以上,且生活质量均有所改善。表明国产、进口rHuEPO疗效无显着性差异,均可安全、有效地改善CRF患者贫血状态。

关键词: 基因重组人红细胞生成素, 尿毒症, 血液透析, 贫血

Abstract: To study and compare the effect of homemade recombinant human erythropoietin(rHuEPO) with that of imported rHuEPOon patients with anemia in chronic renal failure(CRF) undergoing longterm maintenance hemodialysis. Sixty patients with anemia in CRF undergoing longterm hemodialysis in our hospital were divided into two groups at random. The two groups were treated with homemade and imported rHuEPO respectively. The rate of retculocyte of the patients in both groups increased significantly after a week. HCTreached above thirty percent within twelve weeks and the quality of living was also improved after treatment. There are some side effects such as hypertension, headache, hyperkalemia et al in both group. Either homemade or imported rHuEPO could improve the anemia in CRF safely and effectively. There is no significant difference in the effect of treatment between the two groups.

Key words: rHuEPO, uremia, hemodialysis, anemia

中图分类号:

R692.5

孙倩美;邓敏;彭立人. 国产和进口rHuEPO治疗长期血透慢性肾衰竭贫血患者的疗效比较[J]. 首都医科大学学报, 1999, 20(2): 110-112.

Sun Qianmei;Deng Min;Peng Liren. Comparison of the Effect of Homemade rHuEPO and Imported rHuEPO on Treating Patients with Anemia in Chronic Renal Failure Udergoing Long-term Hemodialysis[J]. Journal of Capital Medical University, 1999, 20(2): 110-112.

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