首都医科大学学报 ›› 1999, Vol. 20 ›› Issue (4): 256-258.

• 论著 • 上一篇    下一篇

肾移植中随机HLA配型的研究

贾保祥, 李哲先, 张玉海, 薛竹   

  1. 首都医科大学附属北京友谊医院泌尿科
  • 收稿日期:1998-10-20 修回日期:1900-01-01 出版日期:1999-10-15 发布日期:1999-10-15

Study on Random HLA Matching of Renal Transplantation

Jia Baoxiang, LiZhexian, Zhang Yuhai, Xue Zhu   

  1. Department of Urology, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1998-10-20 Revised:1900-01-01 Online:1999-10-15 Published:1999-10-15

摘要:

为了解随机HLA配型的供受者配合率的多寡,为器官移植的广泛开展提供一些基础性资料,对336例肾移植供受者随机的HLAA、B和DR抗原配型做了分析。HLA6个抗原完全错配率为24.40%(82/336),5个抗原错配率为33.33%(112/336),4个抗原错配率为27.68%(93/336),3个抗原错配率为11.91%(40/336),2个抗原错配率为2.68%(9/336),1个抗原错配率和0个抗原错配率为0.随机HLAA、B和DR1个抗原配合的在HLAA抗原为49.7%(167/336),B抗原为27.7%(93/336),DR抗原为31.8%(107/336).2个抗原配合的在A抗原为4.76%(16/336),B抗原为2.08%(7/336),DR抗原为3.27%(11/336).提示:完全配合的HLA抗原和5个HLA抗原配合的几率极低。在随机肾移植供受者中,HLA抗原A、B和DR抗原位点的2个等位基因完全配合的几率很低。

关键词: 肾移植, HLA配型, 错配

Abstract:

In order to learn the match rate of random matching HLA of the donor orcipients and provide some base date for widespread use of organ transplantation.The antigens matching of HLA A、B and DRofthe dornor recipients were studiedin 336 cases ofrenaltransplantation.The 6、5、4、3、2、1 and 0 mismaching rate were 24.40%、33.33%、27.68%、11.91%、2.68%、0 and 0, respectively.One antigen mismatch rate was 49.7%、27.7% and 31.8% at HLA-A、Band DR antigens ,respectively.Two antigens mismatching rate was 4.76%、2.08% and 3.27% at HLA-A、B and DR antigens, respectively.This study showed that complete matching was rare of six and five HLAantigens and two HLAantigens matching was also rare of HLA-A、Band DRin renaltransplantation.

Key words: renaltransplantation, HLA matching, mismatch

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