当归补血汤治疗脑缺血的实验研究

首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (1): 29-32.

当归补血汤治疗脑缺血的实验研究

冯连泽¹, 杨丽萍¹, 杨莲雪², 王卫², 刘谦², 孙霞², 鲁厚祯²

1. 北京职工医学院解剖学教研室;2. 首都医科大学解剖学教研室

收稿日期:1999-08-20 修回日期:1900-01-01 出版日期:2000-01-15 发布日期:2000-01-15

Study on the Curative Effect on Cerebral Ischemia in Gerbils with the Danggui Complex Mixture

Feng Lianze¹, Yang Liping¹, Yang Lianxue², Wang Wei², Liu Qian², Sun Xia², Lu Houzhen²

1. Department of Anatomy of Beijing Medical Staff College;2. Department of Anatomy, Capital University of Medical Sciences

Received:1999-08-20 Revised:1900-01-01 Online:2000-01-15 Published:2000-01-15

摘要/Abstract

摘要： 为观察当归补血汤对脑缺血的疗效,使用穿梭箱连续观察用当归补血汤组(n=24)和未给药组(n=24)脑缺血模型沙土鼠学习记忆的改变。并取海马区组织块,光镜下观察海马区组织形态的变化。结果：模型组沙土鼠记忆功能比术前显着降低(P<0.01),给药组比未给药组动物的记忆功能恢复得快(P<0.01);模型组海马区组织镜下显示病理性损伤,锥体细胞数目比正常组明显减少(P<0.01),给药组的锥体细胞数目明显多于未给药组(P<0.01).结果提示当归补血汤能够减轻脑缺血后的病理损伤,能够明显改善脑血液循环,促进脑生理机能的恢复,对脑组织具有一定保护作用。

关键词: 当归补血汤, 脑缺血, 蒙古沙土鼠

Abstract: In order to observe the curative effect on cerebral ischemia in the gerbils with the Danggui (Angelica sinensis) complex mixture, the change of the study and memory ability of the gerbils in the cerebral ischemic model group was observed by means of the shuttle box. Morphological change in their hippocampal tissues was observed under the microscopes. The sections of the hippocampal tissue were made use of routine HE, Nills staining. After ligating their unilateral carotid, the memory ability of the gerbils in the model group was significantly lower than that in the preopertive normal value (P<0.01). The regain of memory ability of the gerbils in the treated group with the traditional Chinese medicine (n= 24) was significantly faster than that in the control group (n= 24) (P<0.01). The hippocampal tissue in the model group showed the pathological harm. The pyramid cells of hippocampus in the model group were less than that in the normal group (P<0.01), and the pyramid cells in the treated group were more than those in the control group (P<0.01). The result showed that the Danggui complex mixture could reduce the cerebral pathological harm,promote to regain the physiologic function of postischemic brain,improve the cerebral circulation, and protect on the brain.

Key words: Danggui (Angelica sinensis) complex mixture, cerebral ischemia, Mongolian gerbil

中图分类号:

冯连泽;杨丽萍;杨莲雪;王卫;刘谦;孙霞;鲁厚祯. 当归补血汤治疗脑缺血的实验研究[J]. 首都医科大学学报, 2000, 21(1): 29-32.

Feng Lianze;Yang Liping;Yang Lianxue;Wang Wei;Liu Qian;Sun Xia;Lu Houzhen. Study on the Curative Effect on Cerebral Ischemia in Gerbils with the Danggui Complex Mixture[J]. Journal of Capital Medical University, 2000, 21(1): 29-32.

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