关键词: 氟伐他汀, 血脂, 内膜, 增生

Abstract: To investigate the effects of fluvastatin on blood lipid in inhyperlipidemic model of rabbit after iliac artery endothelial denudation and the relationship between serum lipid and intimal thickening in the study, the New Zealand white rabbits were randomized into three groups: drug treatment group(n=28),non drug treatment group(n=28)and control group(n=7). The atherosclerotic lesions were developed by endothelial denudation with balloon catheter and high dosage of cholesterol diet at the same time. The experimental animals were killed and iliac arteries were removed at 1、2、4、8 weeks after endothelial injury respectively and bloodsamples were taken at the same time. By the methods of routine HE staining, blood lipid measure and image analysis system, observed the effects of fluvastatin on the level of serum TC、TG、LDL-C and the thickness of intima and media,intima/media(I/M) ratio and the relationship between serumlipid and intimal thickening. The level of TC、TG、LDL-C in drug treatment group was remarkably lower than that in non drug treatment group(P<0.05). The thickness of neointima and I/M in drug treatment group was much thinner than that in non drug treatmeant group. Coefficient of linear correlation between intimal thickness and TC、TG、LDL-C were 0.911,0.892,0.942 (P< 0.01) respectively.Fluvastain can lower blood lipid apparently, which may relate its effect to inhibiting excessive thickening of vascular intima.

Key words: fluvastatin, blood lipid, neointima, hyperplasia