黄蜀葵花对肾病综合征模型大鼠肾小管损伤保护作用的研究

首都医科大学学报 ›› 2000, Vol. 21 ›› Issue (3): 209-211.

黄蜀葵花对肾病综合征模型大鼠肾小管损伤保护作用的研究

尹莲芳¹, 刘璐², 弓玉祥¹, 濮家伉³

1. 南京铁道医学院附属医院肾内科;2. 南京铁道医学院放免中心;3. 南京铁道医学院药理教研室

收稿日期:1999-12-23 修回日期:1900-01-01 出版日期:2000-07-15 发布日期:2000-07-15

Protective Effect of Abelmosehus Manihot on Rats Renal Tubular with Nephrotic Syndrome

Yin Lianfang¹, Liu Lu², Gong Yuxiang¹, Pu Jiakang³

1. Department of Nephrology, Affiliated Hospital of Nanjing Railway Medical College;2. Radioimmunoassay Center;3. Department of Pharmacology

Received:1999-12-23 Revised:1900-01-01 Online:2000-07-15 Published:2000-07-15

摘要/Abstract

摘要： 为探讨中药黄蜀葵花对肾病综合征肾小管损伤的保护作用，将每只实验大鼠静脉注射阿霉素5 mg/kg，同时饲以黄蜀葵花,观察其对大鼠尿Ⅲ型胶原、N-乙酰β-D-氨基葡萄糖苷酶（NAG）、β₂微球蛋白（β₂-MG）总排泄量的影响。结果：阿霉素肾病模型大鼠尿Ⅲ型胶原、NAG、β₂-MG水平均显著高于对照组(P<0.01)，而黄蜀葵花治疗组的上述3项指标与对照组相比无差异，且显著低于模型组(P<0.01)。结果提示：阿霉素肾病综合征模型大鼠存在肾小管间质损害，黄蜀葵花对其具有保护作用。

关键词: 黄蜀葵花, 阿霉素肾病大鼠, Ⅲ型胶原, NAG, β₂-MG

Abstract: To investigate the protective effects of Abelmosehus manihot (Am) on rat renal tubular with nephrotic syndrome, the nephrotic rat model was made by tail vein injection of adriamycin 5mg/kg. Am was given and changes of urinary type Ⅲ collagen(C-Ⅲ),N-acetyl-β-D-glucosa minidase(NAG)and β₂ microglobulin(β₂-MG) were observed. It was shown that the excretion of urinary C Ⅲ,NAG and β₂-MG in nephrotic rats were significantly increased as compared with those of the normal control group (P< 0.01). In the group treated with Am, the excretion of urinary C-Ⅲ,NAG and β₂-MG did not increase obviously . Am exerted strong protective effects on rats renal tubular damage with adriamycin induced nephrotic syndrome.

Key words: Abelmosehus manihot, adriamycin-induced nephrotic syndrome, type Ⅲ collagen, N acetyl-β-D-glucosa minidase, β₂-microglobulin

中图分类号:

R692

尹莲芳;刘璐;弓玉祥;濮家伉. 黄蜀葵花对肾病综合征模型大鼠肾小管损伤保护作用的研究[J]. 首都医科大学学报, 2000, 21(3): 209-211.

Yin Lianfang;Liu Lu;Gong Yuxiang;Pu Jiakang. Protective Effect of Abelmosehus Manihot on Rats Renal Tubular with Nephrotic Syndrome[J]. Journal of Capital Medical University, 2000, 21(3): 209-211.