淋巴细胞转化及抑制试验预测肾病患者对激素治疗反应性的研究

首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (1): 39-41.

淋巴细胞转化及抑制试验预测肾病患者对激素治疗反应性的研究

张育, 郭王, 王质刚

首都医科大学附属北京友谊医院肾内科

收稿日期:2000-02-20 修回日期:1900-01-01 出版日期:2001-01-15 发布日期:2001-01-15

Prediction of the Reaction to Glucocorticoid in Patients with Nephrotic Syndrome by Lymphocyte Transform and Restrain Test

Zhang Yu, Guo Wang, Wang Zhigang

Dept. of Renal, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences

Received:2000-02-20 Revised:1900-01-01 Online:2001-01-15 Published:2001-01-15

摘要/Abstract

摘要： 对完成口服泼尼松8周治疗的肾病综合征患者17例,在治疗前取血进行淋巴细胞转化抑制试验,观察其对糖皮质激素治疗的反应性.结果:10例患者对激素治疗敏感,另7例对激素抵抗;而这2组患者体外淋巴细胞培养对激素的反应有显着性差异(P<0.01),甲泼尼龙抑制PHA引发的淋巴细胞转化作用强者,对激素治疗敏感;而甲泼尼龙对淋巴细胞转化抑制作用弱者对激素抵抗.结果表明:体外淋巴细胞转化抑制试验可以作为预测激素治疗效果的方法.

关键词: 淋巴细胞转化抑制试验, 肾病综合征, 糖皮质激素

Abstract: Nineteen patients with nephrotic syndrome received administration of glucocorticoid after they receired the blood test for lymphocyte and restrain test. Seventeen out of 19 patients completed the 8 week observation. Ten patients were sensitive to the glucocorticoid, whereas 7 were resistant to it. There was significant difference in the results of lymphocyte transform and restrain test between the sensitive and resistant patients. The result indicates that the lymphocyte transform and restrain test can be used as a method to predict the reaction to glucocorticoid in patients with nephrotic syndrome.

Key words: lymphocyte transform and restrain test, nephrotic syndrome, glucocorticoid

中图分类号:

R692

张育;郭王;王质刚. 淋巴细胞转化及抑制试验预测肾病患者对激素治疗反应性的研究[J]. 首都医科大学学报, 2001, 22(1): 39-41.

Zhang Yu;Guo Wang;Wang Zhigang . Prediction of the Reaction to Glucocorticoid in Patients with Nephrotic Syndrome by Lymphocyte Transform and Restrain Test[J]. Journal of Capital Medical University, 2001, 22(1): 39-41.

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