PAMAM树状大分子对烟酸增溶效果的影响

首都医科大学学报 ›› 2002, Vol. 23 ›› Issue (1): 17-19.

PAMAM树状大分子对烟酸增溶效果的影响

叶玲¹, 张锦楠¹, 周玉兰¹, 顾微¹, 刘永利¹, 扈金平¹, 朴东旭²

1. 首都医科大学化学教研室;2. 中国康复研究中心人体组织工程研究所

收稿日期:2001-12-18 修回日期:1900-01-01 出版日期:2002-01-15 发布日期:2002-01-15

Solubility Enhancement of Nicotinic Acid in PAMAM Dendrimers

Ye Ling¹, Zhang Jinnan¹, Zhou Yulan¹, Gu Wei¹, Liu Yongli¹, Hu Jinping¹, Piao Dongxu²

1. Department of Chemistry, Capital University of Medical Sciences;2. China Rehabilitation Research Center

Received:2001-12-18 Revised:1900-01-01 Online:2002-01-15 Published:2002-01-15

摘要/Abstract

摘要： 为研究聚酰胺-胺(PAMAM)树状大分子对弱酸性亲脂性药物烟酸的增溶作用,合成了以乙二胺为核的1.0～6.0代(G)PAMAM树状大分子,研究了不同pH值、不同质量浓度的树状大分子对烟酸增溶的影响。结果:pH值、质量浓度均影响PAMAM树状大分子溶液对烟酸的增溶效果。提示:增溶的主要原因是由于树状大分子的氨基与烟酸的羧基之间存在静电作用,PAMAM树状大分子可作为亲脂性弱酸性药物的增溶剂。

关键词: PAMAM树状大分子, 烟酸, 增溶

Abstract: PAMAM dendrimers enhance the solubility of nicotinic acid. PAMAM dendrimers of generation 1 to 6 have been synthesized. The study investigated the effect of pH and concentration of the dendrimers on the solubility enhancement of nicotinic acid. The pH and concentration of the dendrimers influenced the solubility enhancement of nicotinic acid. It suggests that an electrostatic interaction between the carboxyl group of the nicotinic acid and the amine groups of the dendrimers is involved.

Key words: PAMAM dendrimer, nicotinic acid, solubility enhancement

中图分类号:

O631.4

叶玲;张锦楠;周玉兰;顾微;刘永利;扈金平;朴东旭. PAMAM树状大分子对烟酸增溶效果的影响[J]. 首都医科大学学报, 2002, 23(1): 17-19.

Ye Ling;Zhang Jinnan;Zhou Yulan;Gu Wei;Liu Yongli;Hu Jinping;Piao Dongxu. Solubility Enhancement of Nicotinic Acid in PAMAM Dendrimers[J]. Journal of Capital Medical University, 2002, 23(1): 17-19.

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