关键词: 佳乐施, 血液稀释, 凝血功能, 钙离子

Abstract: To compare the changes of coagulation during hypervolemic hemodilution induced by gelofusine(G)or gelofusine containing calcium gluconate(calglucon), 30 neurosurgical patients without heart diseases were randomly allocated into three groups. Hypervolemic hemodilution was induced by rapid infusion, 25 mL/min, of gelofusine(groupⅠ, n=10), gelofusine containing calglucon(0.5 g in 500 mL, groupⅡ, n=10)and of gelofusine containing calglucon(1.0g in 500mL, groupⅢ, n=10)after general anesthesia. Hematocrit(HCT), activate partial thromboplastin time(APTT), prothrombin time(PT)and calcium concentration in serum(Ca²⁺)were tested after anesthesia induction, gelofusine infusion of 500 mL, 1000 mL, 1500 mL and 30 min after infusion, respectively. During hypervolemic hemodilution, PT and APTT were prolonged more in groupⅠthan in groupⅡ and groupⅢ. In groupⅠ, PT and APTT were prolonged by 13.9% and 21.8%, respectively. PT and APTT were prolonged by 10.6% and 12.4%, respectively in groupⅡ, and were prolonged 9.8% and 8.2%, respectively in groupⅢ. Ca²⁺ decreased by 13.8% in groupⅠ, but it did not change significantly in groupⅡ, and increased by 6.4% in groupⅢ, after infusion of 1500 mL gelofusine. The result shows that gelofusine is suitable for hypervolemic hemodilution, but it leads to coagulation disorder which is related to the decreased serum Ca²⁺. Adding 0.5 g calglucon to 500 mL of gelofusine can partly prevent the depression of coagulation.

Key words: gelofusine|hypervolemic hemodilution|coagulation|calcium