关键词: 保健食品, 安全性评价, 减肥

Abstract: The authors have studied the toxicological safety of Tingmei diet cosmetology capsule. The median lethal dose LD₅₀ in mice was 10 g/kg. Ames test, bone marrow cell micronucleus test and the mice sperm abnormality test in mice were negative. In the 30 day toxicity feeding study, the body weight of male mice in 4.50g/kg body weight (the dosage was 100 times more than that for people, the dosage for people is 0.045 g/kg) group increased slowly. Weight gain, forage ingestion, food utilization rate and nonesterified fatty acid (NEFA) were obviously lower than those of the negative control group, then the daily defecation and visceral-body rate of stomach and spermary were obviously higher than those of the negative control group. It was not yet found that Tingmei diet cosmetology capsule obviously affected haematological system, function of liver and kidney, metabolizability of protein, fat or glucose. The result indicates that Tingmei capsules have not harmful effect except affecting weight gain.

Key words: health food, safety evaluation, losing weight