关键词: 缺血预适应, 糖尿病, 心肌梗死, 心绞痛, 心室舒张功能

Abstract: To investigate the short-term effects of ischemic preconditioning pectoris on left ventricular diastolic function in diabetic patients with acute myocardial infarction, 222 patients with first acute myocardial infarction were studied. 95 without diabetes were divided into group A(with IP) and group B (without IP). Another 127 with diabetes were divided into group C(with IP ) and group D(without IP). The effects of IP on peak creatine kinase value and left ventricular diastolic function were analyzed separately. Results: The peak creatine kinase value and the peak creatine kinase MB fractions were significantly lower in group A than those in the other groups (P<0.01 for each comparion). At the same time, the ratio of the early peak velocity/the late peak velocity in diastole of mitral flow (E/A) and the incidence of E/A<1 were significantly lower in group A than those in the other groups (P<0.05 or P< 0.01), while there was no significant difference between those in the other groups (P>0.05). Conclusion: Ischemic preconditioning could limit infarct size, protect the left ventricular diastolic function in non-diabetic patients with acute myocardial infarction. However, such beneficial effects of ischemic preconditioning have not been observed in diabetic patients.

Key words: ischemic preconditioning, diabetes, myocardial infarction, angina pectoris, ventricular diastolic function