脊髓损伤中枢性疼痛大鼠损伤节段上WDR神经元的电生理变化

首都医科大学学报 ›› 2004, Vol. 25 ›› Issue (1): 12-14.

脊髓损伤中枢性疼痛大鼠损伤节段上WDR神经元的电生理变化

赵晓东¹, 郑泓溶², 赵峰³, 熊开宇²

1. 河北医科大学附属第二医院外科;2. 北京体育大学运动生理学教研室;3. 首都医科大学环境卫生与劳动卫生教研室

收稿日期:2003-07-13 修回日期:1900-01-01 出版日期:2004-01-15 发布日期:2004-01-15
通讯作者: 赵峰

Electrophysiological Changes of WDR Neurons in Spinal Cord Above Injury Plane in Rats with Chronic Central Pain Following Spinal Cord Injury

Zhao Xiaodong¹, Zheng Hongrong², Zhao Feng³, Xong Kaiyu²

1. Department of Surgery, The second Hospital of Hebei, Affiliate of Hebei Medical University;2. Department of Sports Physiology, Beijing University of Physical Education;3. College of Public Health and Family Medicine, Capital University of Med ical Science

Received:2003-07-13 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

摘要/Abstract

摘要： 为研究脊髓损伤后慢性中枢性疼痛(CCP)的发生机制,将大鼠以重物坠落法造成脊髓损伤CCP模型,记录损伤平面上广动力范围(WDR)神经元诱发放电的变化,并以正常大鼠为对照进行比较。发现:具有CCP大鼠的WDR神经元的诱发电位晚成分的放电阈值、潜伏期、放电频率、放电数与对照相比有非常显著性差异(P<0.01);早成分除放电数有非常显著性差异(P<0.01)外,其他指标与对照组相比无显著差异。提示:脊髓损伤后上位中枢WDR神经元的高兴奋性可能是CCP的原因.

关键词: 中枢性疼痛, 脊髓损伤, WDR神经元

Abstract: To investigate the mechanism of chronic central pain(CCP) after spinal cord inju ry(SCI), the model of CCP was made by weight dropping, then recording the evoked potential of wide dynamic rang (WDR)neurons in spinal cord above the lesion plan e. Compared with the normal rats, the number of early discharges of stimulation -evoked responses significantly decreased. As to the late discharges of stimula tion-evoked responses, respectively the threshold decreased, the latent per iod was shortened, the frequency and the number increased significantly compared with the normal rats. The result suggests that the high excitability of WD R neurons in center above the injury plane may be the reason of CCP after SCI.

Key words: chronic central pain, wide dynamic ra nge neurons, spinal cord injury

中图分类号:

R651.2
R338

赵晓东;郑泓溶;赵峰;熊开宇. 脊髓损伤中枢性疼痛大鼠损伤节段上WDR神经元的电生理变化[J]. 首都医科大学学报, 2004, 25(1): 12-14.

Zhao Xiaodong;Zheng Hongrong;Zhao Feng;Xong Kaiyu. Electrophysiological Changes of WDR Neurons in Spinal Cord Above Injury Plane in Rats with Chronic Central Pain Following Spinal Cord Injury[J]. Journal of Capital Medical University, 2004, 25(1): 12-14.

[1]	王浩, 李伟, 张丽, 于晓刚. 针刺治疗卒中后中枢性疼痛的随机对照研究[J]. 首都医科大学学报, 2017, 38(1): 63-66.
[2]	吕振, 姜树东, 白金柱, 张军卫, 王方永, 洪毅. 电学治疗在脊髓损伤领域从基础研究转化为临床技术的研究进展[J]. 首都医科大学学报, 2015, 36(5): 805-808.
[3]	杨德刚, 李建军, 杨明亮, 胡安明, 顾蕊, 杜良杰. 脊髓切开术治疗创伤性脊髓损伤的手术时机研究进展[J]. 首都医科大学学报, 2015, 36(1): 147-150.
[4]	赖光辉, 李玄英, 倪家骧. 全脊髓毁损术治疗截瘫后神经痛的临床研究[J]. 首都医科大学学报, 2014, 35(1): 10-12.
[5]	王琦, 倪家骧. CT引导下脊髓射频热凝术治疗脊髓损伤性神经病理性疼痛[J]. 首都医科大学学报, 2014, 35(1): 18-22.
[6]	戴红;胥少汀;肖忠新;张洪;谢作磊;张立军;陈迎朝;张立仁;王元身;戴珂. 脊髓损伤致自发痛动物模型的建立[J]. 首都医科大学学报, 2005, 26(6): 670-672.
[7]	胡永生;李勇杰;石长青;张宇清;马凯;张晓华;朱宏伟. 中脑加扣带回联合毁损术治疗中枢性疼痛的应用研究[J]. 首都医科大学学报, 2005, 26(4): 386-388.
[8]	马育平;高秀来;陈亚亮;陆涛;宋一志;景朋;韩凤岳;苏静;刘卫东;张平;常超英;刘恩. 中药脊髓I号对脊髓损伤大鼠背根神经节一氧化氮合酶表达的影响[J]. 首都医科大学学报, 2003, 24(1): 19-22.
[9]	黄红云;陈琳;王洪美;修波;李炳辰;王锐;张健;张峰;顾征;李荧;宋英伦;郝伟. 年龄对嗅鞘细胞移植治疗脊髓损伤疗效的影响[J]. 首都医科大学学报, 2003, 24(1): 56-59.
[10]	曹静宜;王兰;常永顺;王继琛;柯美云. 创伤性脊髓损伤病人的固体胃排空及吗丁啉的治疗观察[J]. 首都医科大学学报, 1992, 13(4): 277-281.