急性胰腺炎病因的病理学探讨

首都医科大学学报 ›› 2004, Vol. 25 ›› Issue (3): 307-310.

急性胰腺炎病因的病理学探讨

陈瑞芬¹, 赵敏¹, 王民², 王小平¹, 周以键¹, 王珏¹

1. 首都医科大学病理解剖学教研室;2. 首都医科大学电镜室

收稿日期:2003-07-17 修回日期:1900-01-01 出版日期:2004-07-15 发布日期:2004-07-15

Investigation of Pathogenesis in Acute Pancreatitis

Chen Ruifen¹, Zhao Min¹, Wang Min², Wang Xiaoping¹, Zhou Yijian¹, Wang Jue¹

1. Department of Pathology, Capital University of Medical Sciences;2. Department of Electron Microscope, Capital University of Medical Sciences

Received:2003-07-17 Revised:1900-01-01 Online:2004-07-15 Published:2004-07-15

摘要/Abstract

摘要： 胰胆管内逆行注射5.0%牛磺胆酸钠溶液,建立大鼠急性出血坏死性胰腺炎(AHNP)模型,通过光镜普通染色、PTH染色及电镜超微结构方法,对诱导AHNP后5min至6h胰腺的病变及微循环的形态学表现进行观察,以探讨胰腺炎的病因和发病机制.发现:诱导AHNP后主要病变为:胰腺组织出血、坏死,白色血栓、微血栓及混合血栓形成;并且随着诱导时间的延长病变加重.提示:胰腺炎的发生及发展与自身消化及微循环障碍有关.

关键词: 急性出血坏死性胰腺炎, 病理变化, 自身消化, 微循环障碍

Abstract: Observations of pathologic morphology were made at the early phase of acute hemorrhagic and necrotic pancreatitis(AHNP), to investigate pathogenesis of acute pancreatitis.AHNP was induced in rats(30, weight 300～350 g) by intraductal administration of 5% sodium taurocholate.The pathologic morphologic changes of pancreatic tissue were examined by light microscope by HE and PTH and electron microscope after induced 5 min to 6 h.Main pathological changes: hemorrhage and necrosis appear in pancreas, fibrin thrombus, white thrombus and mixed thrombus in small vessels.With the development of the disease pathological changes were aggravated.The result suggests: AHNP is associated with self-digestion and microcirculation disturbance.

Key words: acute hemorrhagic and necrotic pancreatitis (AHNP), pathologic change, self-digestion, microcirculation disturbance

中图分类号:

R657.5⁺1

陈瑞芬;赵敏;王民;王小平;周以键;王珏. 急性胰腺炎病因的病理学探讨[J]. 首都医科大学学报, 2004, 25(3): 307-310.

Chen Ruifen;Zhao Min;Wang Min;Wang Xiaoping;Zhou Yijian;Wang Jue. Investigation of Pathogenesis in Acute Pancreatitis[J]. Journal of Capital Medical University, 2004, 25(3): 307-310.

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