槲皮素对缺血再灌注大鼠心肌损伤的保护作用

首都医科大学学报 ›› 2004, Vol. 25 ›› Issue (3): 311-313.

槲皮素对缺血再灌注大鼠心肌损伤的保护作用

曹文军, 陈瑞芬, 刘国贞

首都医科大学病理解剖学教研室

收稿日期:2004-02-20 修回日期:1900-01-01 出版日期:2004-07-15 发布日期:2004-07-15

Protecting Effects of Quercetin on Myocardium Ischemia Repurfusion Injury in Rats

Cao Wenjun, Chen Ruifen, Liu Guozhen

Department of Pathology, Capital University of Medical Sciences

Received:2004-02-20 Revised:1900-01-01 Online:2004-07-15 Published:2004-07-15

摘要/Abstract

摘要： 采用大鼠心肌缺血再灌注模型,观察槲皮素对缺血再灌注心肌损伤的保护作用.实验大鼠分为假手术组、缺血再灌注组、槲皮素组和维拉帕米组.观察槲皮素对各组大鼠血清肌酸磷酸激酶(CPK)、谷胱甘肽过氧化物酶(GSH-Px)以及ATP酶的影响,并通过光镜及电镜观察病理学改变.结果表明:槲皮素可显著降低CPK活性,升高GSH-Px和ATP酶活性.提示:槲皮素对缺血再灌注心肌具有保护作用,病理结果进一步证实了这一点.推测其机制可能与抗脂质过氧化反应及增强心肌的能量代谢、减轻钙超载有关.

关键词: 槲皮素, 心肌缺血再灌注, 心肌损伤

Abstract: Protective effects of quercetin on myocardium ischemia repurfusion injury were studied in rats.Wistar rats were divided into 6 groups: pseudo operation; ischemia reperfusion operation; ischemia reperfusion with quercetin 0.2 mg/kg, 1.0 mg/kg and 5.0 mg/kg; ischemia reperfusion with verapamil 1 mg/kg.The results showed that quercetin possesses protective effects on myocardium ischemia reperfusion injury in rats and its mechanism may be related to inhibition of lipid peroxidation of quercetin.

Key words: quercetin, myocardial ischemia reperfusion, myocardial injury

中图分类号:

R364.1

曹文军;陈瑞芬;刘国贞. 槲皮素对缺血再灌注大鼠心肌损伤的保护作用[J]. 首都医科大学学报, 2004, 25(3): 311-313.

Cao Wenjun;Chen Ruifen;Liu Guozhen. Protecting Effects of Quercetin on Myocardium Ischemia Repurfusion Injury in Rats[J]. Journal of Capital Medical University, 2004, 25(3): 311-313.

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