17β-雌二醇及植物雌激素α-玉米赤霉醇致去卵巢大鼠子宫增大作用的比较

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (1): 51-54.

17β-雌二醇及植物雌激素α-玉米赤霉醇致去卵巢大鼠子宫增大作用的比较

王雯, 杨慧, 王红霞, 张立克

首都医科大学病理生理学教研室

收稿日期:2004-06-11 修回日期:1900-01-01 出版日期:2005-02-24 发布日期:2005-02-24

17β-estradiol and Phytoestrogen α-zearalanolon Uterus Enlarging in Ovariectomized Rats

Wang Wen, Yang Hui, Wang Hongxia, Zhang Like

Department of Pathophysiology, Capital University of Medical Sciences

Received:2004-06-11 Revised:1900-01-01 Online:2005-02-24 Published:2005-02-24

摘要/Abstract

摘要：

为观察植物雌激素α-玉米赤霉醇(ZAL)对去卵巢大鼠子宫增大的影响, 并对其与雌二醇的作用进行比较分析, 建立大鼠去卵巢模型, 分别补充17β-雌二醇(E₂)或ZAL(1mg/kg, 3d注射1次, 共35d)。用放射免疫法测定大鼠血浆雌二醇质量浓度;分离子宫, 计算子宫质量(g)/体质量(kg)的比值, 制作子宫病理切片。发现:去卵巢+补充17β-雌二醇组的血浆雌二醇质量浓度较单纯去卵巢组明显升高, 去卵巢+补充ZAL组的血浆雌二醇质量浓度明显低于去卵巢+补充17β-雌二醇组;ZAL对子宫增大的影响很弱(子宫质量(g)/体质量(kg)=0.66), 明显低于17β-雌二醇〔子宫质量(g)/体质量(kg)=1.96〕;镜下见17β-雌二醇组大鼠子宫内膜出现显著囊性增生, 而ZAL组未见增生性病变。以上结果表明ZAL对子宫的刺激很小, 明显优于17β-雌二醇, 可能作为一种选择性雌激素受体调节剂而发挥作用。

Abstract:

The aim of this study was to investigate and compare the effects of 17β-estrad iol and phytoestrogen α-zearalanol(ZAL) on uterus enlarging in ovariectomized(OVX) rats. OVX rats were injected intramuscularly with 17β-estradiol or ZAL (1 mg/kg) for five weeks. The concentrations of plasma estradiol were measured by radioimmunoassay. Separate the uterus from rats and calculate the ratio of ut eri weight(g)/body weight(kg) then make pathology slice of uterus tissue. It was found that plasma estradiol levels of OVX+17β-estradiol rats were signifi cantly higher than th at of OVX rats, while estradiol levels of OVX+ZAL were significantly lower than that of OVX+17β-estradiol rats. ZAL had slighter effect on uterus enlarging in ovariectomized rats compared with 17β-estradiol. These results suggest that Z AL has less stimulation on uterus than 17β-estradiol, which maybe work as one of selectively estrogen receptor modulator(SERM).

Key words: phytoestrogen, &alpha, -zearalanol, 17&beta, -estradiol, variectomized rats, uterus

中图分类号:

Q492.5

王雯;杨慧;王红霞;张立克. 17β-雌二醇及植物雌激素α-玉米赤霉醇致去卵巢大鼠子宫增大作用的比较[J]. 首都医科大学学报, 2005, 26(1): 51-54.

Wang Wen;Yang Hui;Wang Hongxia;Zhang Like . 17β-estradiol and Phytoestrogen α-zearalanolon Uterus Enlarging in Ovariectomized Rats[J]. Journal of Capital Medical University, 2005, 26(1): 51-54.

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