首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (4): 479-481.

• 论著·临床研究 • 上一篇    下一篇

单相速发型多脏器功能障碍综合征动物模型的研究

任添华1, 姜悦2, 任爱民3, 张淑文3, 王宝恩3   

  1. 1. 首都医科大学附属北京天坛医院消化内科;2. 首都医科大学附属北京天坛医院心血管内科;3. 首都医科大学附属北京友谊医院感染暨急救医学科
  • 收稿日期:2005-03-28 修回日期:1900-01-01 出版日期:2005-08-24 发布日期:2005-08-24

Study of Animal Model of the PromoPted One Phase Multiple Organ Dysfunction Syndrome in Pigs

Ren Tianhua1, Jiang Yue2, Ren Aimin3, Zhang Shuwen3, Wang Baoen3   

  1. 1. Department of Gastroeterology, Beijing Tiantan Hospital, Capital University of Medical Sciences;2. Departmentof Cardiovascular, Beijing Tiantan Hospital, Capital University of Medical Sciences;3. Department of Infection andCritical Care, Beijing Friendship Hospital, Capital University of Medical Sciences
  • Received:2005-03-28 Revised:1900-01-01 Online:2005-08-24 Published:2005-08-24

关键词: 多脏器功能障碍综合征, 动物模型, 大肠杆菌

Abstract:

Objective The purpose of the study was to provide a simple and useful MODS animal model.Methods 16 one-year-old male swines whose weight was 20~25 kg were selected. Colon bacillus (17×108/kg)was injected into right jugular. Serum endotoxins, blood routine, blood gas analysis, mean arterial pressure(MAP), heart rate (HR), temperature and breath rate were examined 1, 3, 5, and 7 h after injection respectively.Results 3 h after models were made with standard colon bacillus, all animals had endotoxemia; 5 h later, and 100% animals had MODS.Conclusion An useful animal model of MODS is provided by the present study.

Key words: MODS, animal model, colon bacillus

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