儿童肺炎链球菌对β-内酰胺类、大环内酯类和氟喹诺酮类抗菌药物敏感性研究

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (5): 517-520.

儿童肺炎链球菌对β-内酰胺类、大环内酯类和氟喹诺酮类抗菌药物敏感性研究

王咏红, 佟月娟, 俞桑洁, 杨永弘

首都医科大学附属北京儿童医院儿科研究所微生物室

收稿日期:2005-08-20 修回日期:1900-01-01 出版日期:2005-10-24 发布日期:2005-10-24

Resistance of Streptococcus Pneumoniae to β-lactams Macrolides and Fluoroquinolone among Children

Wang Yonghong, Tong Yuejuan, Yu Sangjie, Yang Yonghong

Department of Microbiology, Pediatric Research Institute, Beijing Children's Hospital, Capital University of Medical Sciences

Received:2005-08-20 Revised:1900-01-01 Online:2005-10-24 Published:2005-10-24

摘要/Abstract

摘要：

目的了解2002—2004年北京儿童医院门诊5岁以下呼吸道感染儿童鼻咽拭子中分离出的肺炎链球菌,对β-内酰胺类、大环内酯类和氟喹诺酮类抗菌药物的耐药性。方法使用E试验法(E-test)对114株肺炎链球菌进行抗菌药物的敏感性试验。结果 114株肺炎链球菌对青霉素不敏感率为36%,对阿莫西林/棒酸全部敏感,对头孢菌素中头孢曲松不敏感率为6.1%,头孢呋辛为30.7%,头孢克洛为29%,大环内酯类耐药率在90%左右,全部菌株对氟喹诺酮类敏感。结论儿童肺炎链球菌对青霉素和头孢二代抗菌药物不敏感率为29%～36%,对大环内酯类耐药在90%左右,未发现对氟喹诺酮类耐药菌株。

关键词: 肺炎链球菌, 细菌耐药, 氟喹诺酮类抗菌药物

Abstract:

Objective To investigate resistance to β-lactams,macrolides and fluoroquinolone in carriage isolates of Streptococcus pneumoniae in nasopharynx among children under 5 with respiratory infection who attended a general outpatient department at Beijing Children's Hospital from 2002 to 2004.Methods Antimicrobials sensitivity testing of Streptococcus pneumoniae E-test methods and the results were analyzed according to NCCLS(2002).Results Resistance of pneumococci to penicillin was 36%,amoxycillin/clavulanate was 0%, ceftriaxone was 6.1%,cefaclor was 29%,cefuroxime was 30.7%,macrolides were around 90%,and fluoroquinolone were 0%.Conclusion Non-susceptible to penicillin and the second cephalosporin of Streptococcus pneumoniae isolates among children ranged from 29%～36%,and to macrolides were about 90%.

Key words: Streptococcus pneumoniae, bacterial resistance, fluoroquinolone

中图分类号:

R378.1⁺2

王咏红;佟月娟;俞桑洁;杨永弘. 儿童肺炎链球菌对β-内酰胺类、大环内酯类和氟喹诺酮类抗菌药物敏感性研究[J]. 首都医科大学学报, 2005, 26(5): 517-520.

Wang Yonghong;Tong Yuejuan;Yu Sangjie;Yang Yonghong. Resistance of Streptococcus Pneumoniae to β-lactams Macrolides and Fluoroquinolone among Children[J]. Journal of Capital Medical University, 2005, 26(5): 517-520.