COX-2在口腔白斑、口腔扁平苔藓及口腔鳞状细胞癌中的表达

首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (3): 283-286.

COX-2在口腔白斑、口腔扁平苔藓及口腔鳞状细胞癌中的表达

吴洪儒, 孙正, 汤晓飞, 王凤光, 汪育苗

首都医科大学附属北京口腔医院

收稿日期:2006-04-20 修回日期:1900-01-01 出版日期:2006-06-24 发布日期:2006-06-24

The Expression of Cyclooxygenase-2 in Oral Leukoplakia,Lichen Planus and Squamous Cell Carcinoma

Wu Hongru, Sun Zheng, Tang Xiaofei, Wang Fengguang, Wang Yumiao

Beijing Stomatology Hospital, Capital University of Medical Sciences

Received:2006-04-20 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24

摘要/Abstract

摘要： 目的通过观察COX-2在口腔黏膜白斑(OLK)、口腔扁平苔藓(OLP)及口腔鳞状细胞癌(SCC)中的表达情况,探讨其在口腔癌发生过程中的意义.方法用免疫组化方法检测COX-2在51例口腔黏膜白斑(单纯增生15例,伴异常增生36例)、34例口腔扁平苔藓(单纯扁平苔藓19例,伴异常增生15例)、52例口腔鳞状细胞癌、10例正常口腔黏膜中的表达情况.采用图像分析系统计数阳性细胞率.应用统计学方法分析COX-2在不同病变中的表达.结果 COX-2在白斑单纯增生组6.7%(1/15)为强阳性表达,白斑异常增生组强阳性的表达率为50%(18/36);在单纯扁平苔藓组15.8%(3/19)为强阳性表达;扁平苔藓异常增生组强阳性的表达率为33.3%(5/15);鳞状细胞癌有7.7%(4/52)呈强阳性表达.COX-2在白斑异常增生组强阳性的表达率显著高于单纯白斑和鳞状细胞癌组(P＜0.01),在扁平苔藓异常增生组明显高于单纯扁平苔藓和鳞状细胞癌组(P＜0.05).单纯白斑、扁平苔藓组与鳞癌组相比较,COX-2的表达无明显差异(P＞0.05).结论 COX-2在口腔癌变过程中是一个早期事件,可能成为化学预防作用的重要靶点.

关键词: COX-2, 口腔黏膜白斑, 口腔扁平苔藓, 口腔鳞状细胞癌

Abstract: Objective To study the role of the cyclooxygenase (COX)2 in the genesis of squamous cell by means of observation on its expression in oral leukoplakia, lichen planus and squamous cell carcinoma.Methods COX-2 expression was observed in 51 cases of OLK (15 OLK, 36 OLK with dysplasia), 34 cases of OLP ( 19 OLP, 15 OLP with dysplasia),52 cases of SCC and 10 cases of normal oral mucosa by immunohistochemistry. The number of positive cells was counted by image analysis system and COX-2 expression was analyzed by statistical method.Results The strong expression of COX-2 in the OLK was 6.7% (1/15); 50% (18/36) in the OLK with dysplasia; 15.8% (3/19) in the OLP; 33.3% (5/15) in the OLP with dysplasia; and 7.7% (4/52) in the SCC respectively. The positive rate was higher in the OLK with dysplasia than in the OLK or SCC (P<0.01). The higher positive rate was detected in the OLP with dysplasia than in the OLP or SCC (P<0.05). There were no significant differences between OLK, OLP and SCC (P>0.05).Conclusion COX-2 overexpression occurred in the early stage of oral carcinogenesis, it could be an important target for the chemical prevention and therapy.

Key words: COX-2, oral leukoplakia, oral lichen planus, squamous cell carcinoma

中图分类号:

R739.8

吴洪儒;孙正;汤晓飞;王凤光;汪育苗. COX-2在口腔白斑、口腔扁平苔藓及口腔鳞状细胞癌中的表达[J]. 首都医科大学学报, 2006, 27(3): 283-286.

Wu Hongru;Sun Zheng;Tang Xiaofei;Wang Fengguang;Wang Yumiao . The Expression of Cyclooxygenase-2 in Oral Leukoplakia,Lichen Planus and Squamous Cell Carcinoma[J]. Journal of Capital Medical University, 2006, 27(3): 283-286.

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