首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (3): 408-409.

• 临床研究 • 上一篇    下一篇

幽门螺杆菌临床常用检测方法的比较

王玉兰1, 吴燕川1, 沙中芬2   

  1. 1. 首都医科大学宣武医院中心实验室;2. 首都医科大学宣武医院消化科
  • 收稿日期:2004-08-31 修回日期:1900-01-01 出版日期:2006-06-24 发布日期:2006-06-24

Comparison of Commonly Used Clinical Methods for the Detection of H. pylori

Wang Yulan1, Wu Yanchuan1, Sha Zhongfen2   

  1. 1. Central Laboratory, Xuanwu Hospital, Capital University of Medical Sciences;2. Department of Gastroenterology, Xuanwu Hospital, Capital University of Medical Sciences
  • Received:2004-08-31 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24

摘要: 目的 通过对几种幽门螺杆菌检测方法的灵敏性和特异性进行比较,为临床提供一种检测幽门螺杆菌的最佳方案.方法在胃窦大弯侧近幽门2 cm处取活组织并抽血2 mL,采用快速尿素酶试验法、组织染色法、13C-尿素呼气试验、ELISA法进行幽门螺杆菌测定.结果快速尿素酶试验法、组织银染法、13C-尿素呼气试验、ELISA法的灵敏度分别为84.6%、95.6%、97.8%、89.0%,特异性分别为77.2%、78.9%、88.2%、75.6%.结论 4种方法中以13C-尿素呼气试验灵敏性和特异性最高.快速尿素酶法简单、易行、价廉;组织学染色准确率较高;血清HP抗体测定和13C-尿素呼气试验为非侵入性,准确率也较高,患者依从性好.

关键词: 幽门螺杆菌, 测定方法, 比较

Abstract: Objective It was reported that H.pylori is one of the high risk factors in chronic gastritis, ulcer, and gastric cancer, The aim of this study is to provide a useful method for detecting H. pylori.Methods In 150 patients H.pylori was detected with ureasetesting, warthin-starry histology, ELISA technique, and 13 C-breathtest-instructions.Results The sensitivities of the four methods are: ureasetesting (84.6%), histology (95.6%), 13 C-breathtest-instructions (97.8%), ELISA technique(89.0%). The speciticities of the four methods are urease testing (77.2%), histology (78.9%), 13 C-breathtest-instructions (88.2%), ELISA technique(75.6%) respectively.Conclusion Histology are the method with best accuracy for the detection of H.pylori.

Key words: H.pylori, detected method, contrast

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