关键词: 移植后糖尿病, 免疫抑制药物浓度, 体质量指数

Abstract: Objective To study the risk factors of post-transplantation diabetes mellitus(PTDM). Methods A retrospective analysis was performed in 101 cadaveric renal transplantation patients, without previously known diabetes, during the period from January 2003 to October 2006. The patients were divided into two groups: PTDM and no-PTDM. The two groups were compared for age, sex, family history of diabetes mellitus, pre-transplanting BMI(body mass index), baseline immunosuppressive agents. Results 1) The incidence of PTDM was about 11.9% in these 101 patients. 2) There were great differences between the two groups in terms of age, family history of diabetes mellitus, pre-transplanting BMI . The PTDM cases were prone to have older ages, higher pre-transplanting BMI and more commonly with family history of diabetes mellitus. 3) There was no difference between the two groups in terms of sex and baseline immunosuppressive agents. Conclusion This study shows that the risk factors of PTDM include: older age, family history of diabetes mellitus, higher pre-transplant BMI. Sex is not a risk factor for development of PTDM. Compared to patients on cyclosporine use, tacrolimus is not a risk factor for development of PTDM.

Key words: post-transplantation diabetes mellitus, immunosuppressive agent, body mass index