首都医科大学学报 ›› 2009, Vol. 30 ›› Issue (2): 182-184.

• 肺循环疾病的基础研究 • 上一篇    下一篇

Wnt信号通路的生物学效应及其与肺部疾病的关系

于晓敏1,2,3, 王辰1,3, 王军2,3   

  1. 1. 首都医科大学附属北京朝阳医院呼吸内科,北京呼吸疾病研究所;2. 首都医科大学基础医学院生理教研室;3. 首都医科大学呼吸病学系
  • 收稿日期:2008-12-18 修回日期:1900-01-01 出版日期:2009-04-21 发布日期:2009-04-21
  • 通讯作者: 王辰, 王军

The Biologic Significance of Wnt Signaling Pathway in Lung Disease

YU Xiao-min1,2,3, WANG Chen1,3, WANG Jun2,3   

  1. 1. Department of Respiratory Disease, Beijing Chaoyang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine;2. Department of Physiology, School of Basic Medical Sciences, Capital Medical University;3. Department of Respiratory, Capital Medical University
  • Received:2008-12-18 Revised:1900-01-01 Online:2009-04-21 Published:2009-04-21

摘要:

Wnt信号转导通路(Wnt 通路)是一条在进化上保守的信号途径,它主要由经典Wnt/β-catenin信号途径和非经典的Wnt信号途径(Wnt/平面细胞的极性途径和Wnt/Ca2+途径)组成。其生物学效应广泛,可调控细胞的黏附、迁移、增生和凋亡等。作为一条与多种疾病密切关系的信号转导通路,其在肺部疾病发生、发展中所起的重要作用也逐渐被揭示。

关键词: Wnt信号, 肺动脉高压, 哮喘, 特发性肺纤维化, 肺癌

Abstract:

The Wnt signaling pathway is a highly conserved signaling pathway. It mainly consists of the canonical Wnt/β-catenin pathway and the non-canonical pathway〔the Wnt/planar cell polarity(PCP) pathway and the Wnt/Ca2+ pathway〕. Wnt pathway is involved in a wide range of biological functions, such as cell adhesion, migration, proliferation and apoptosis. Recently, accumulating evidence have suggested that the activation of Wnt signaling pathway is substantially involved in the pathogenesis of several pulmonary diseases, such as idiopathic pulmonary arterial hypertension, asthma, idiopathic pulmonary fibrosis and lung cancer. This review focuses on the biological significance of Wnt signaling pathway in lung diseases.

Key words: Wnt signaling, pulmonary arterial hypertension, asthma, idiopathic pulmonary fibrosis, lung cancer

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