关键词: 2型糖尿病, 糖调节受损, 危险因素

Abstract: Objective To understand the main risk factors of type 2 diabetes(2DM) and impaired glucose regulation(IGR) in a rural population of Beijing suburb. Methods The study was conducted on 1 873 rural residents who participated in physical examination of Nanfaxin district of Beijing. The content of physical examination included: 1 Questionnaire survey: general condition, past medical history, family history.2 Physical examination items: body height, body mass, waist line, hip circumference and blood pressure etc. 3 Laboratory examinations: fasting blood glucose(FBG), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), etc. Subjects were tested for blood glucose of 2 hours after orally taking 75 g glucose if their FBG was above 5.5 mmol/L and had no diabetic history. Subjects were divided into 2DM group, IGR group and normal glucose group(NBG) according to the diagnostic criteria of diabetes in 1999 published by WHO. Results 1 360 patients with 2DM, and 129 patients with IGR, 1 384 subjects with NBG were involved in the analysis of results. Compared to subjects with NBG, patients with 2DM and IGR were significantly higher in age, body mass, waist line, body mass index(BMI), waist-to hip ratio(WHR), systolic blood pressure, diastolic blood pressure, TC, TG, LDL-C and patients with 2DM were significantly lower in HDL-C(P<0.05~0.01). 2 Analysis of relation between research factors and 2DM with logistic regression showed that there were significant differences in age, diabetic family history, waist circumference, WHR, TG and LDL-C between 2DM patients and subjects with NBG(OR: 1.066, 8.943, 1.650, 1.744, 1.196, 1.411, P<0.01). The 6 factors were risk factors of 2DM. Logistic regression also represented that age, diabetic family history, BMI, TG, LDL-C were risk factors of IGR(OR: 1.049, 3.276, 1.586, 1.130, 1.431, P<0.05). Conclusion Compared to subjects with normal glucose, patient with IGR and 2DM have similar levels of blood pressure, blood lipid and obesity. Obesity and IGR is the prelude of 2DM and has high risk of cardiovascular disease. Therefore, effective screening of rural population and control of known risk factors for 2DM, such as overweight and obesity, is good to prevent and reduce 2DM and cardiovascular disease.

Key words: type 2 diabete, impaired glucose regulation, risk factor