首都医科大学学报 ›› 2010, Vol. 31 ›› Issue (1): 84-87.

• 老年病的基础与临床研究 • 上一篇    下一篇

突触后致密区与突触可塑性

冯波1,2, 胡鹏3, 王蓉1   

  1. 1. 首都医科大学宣武医院中心实验室, 神经变性病教育部重点实验室; 2. 滨州医学院附属医院神经内科;3. 滨州医学院附属医院骨科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-21 发布日期:2010-02-21
  • 通讯作者: 王蓉

Postsynaptic Dense Area and Synaptic Plasticity

FENG Bo1,2, HU Peng3, WANG Rong1   

  1. 1. Central Laboratory, Xuanwu Hospital, Capital Medical University; Key Laboratory for Neurodegenerative Diseases of Ministry of Education; 2. Department of Neurology, Affiliated Hospital of Binzhou Medical College; 3. Department of Orthopedics, Affiliated Hospital of Binzhou Medical College
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-02-21 Published:2010-02-21
  • Contact: WANG Rong

摘要: 突触是神经元之间的连接部位,生物信号从突触前膜经突触传递到突触后膜。突触的数量和功能发生改变可引起突触可塑性的改变,进而影响学习记忆能力。突触后致密区与突触可塑性的关系十分密切,对于维持突触发挥正常功能至关重要。本文从突触后致密区的发现和组成成分、参与突触可塑性的主要神经递质、以及突触后致密区与突触可塑性的关系等3方面研究进展做一简要综述。

关键词: 突触后致密区, 可塑性, 学习记忆

Abstract: Synapses are connections between neurons, biological signals are transferred from the presynaptic membrane by the synaptic transmission to the postsynaptic membrane. Changes in the number and function of synapsis can cause changes in synaptic plasticity, thereby can affect learning and memory. Postsynaptic dense area and the close relationship between synaptic plasticity are essential for the maintenance of synaptic function properly. In this article, we make a brief overview on the research of postsynaptic dense area including its discovery and composition, participation in a major neurotransmitter in synaptic plasticity, as well as the relationship between postsynaptic dense area and the synaptic plasticity.

Key words: postsynaptic density area, plasticity, learning and memory

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