关键词: 大脑中动脉闭塞模型, 肠动力, 肠黏膜

Abstract: Objective To determine the change of intestinal mucosa, intestinal motility and their relationship. Methods Forty-eight Wistar rats were randomly divided into control group(n=8) and middle cerebral artery occlusion(MCAO) group(n=40). MCAO group was further divided into 3 h, 6 h, 12 h, 24 h, 48 h after the cerebral arterial thrombosis, each subgroup had 8 rats. Along with the application of transluminal techniques of Longa to create the focal cerebral ischemia model in rats. The damages of intestinal mucosa were observed under light and electron microscopy and determine the intestinal motility at each special time point using the methylene blue staining method. Results There was significant difference in the intestinal motility between control and MCAO groups(P<0.05). There was statistical significance of difference between 3 h group and 6 h group(P<0.01), and there was no statistical significance of difference between 6 h group and 12 h group, 12 h group and 24 h group, 24 h group and 48 h group(P>0.05). Damage of intestinal mucosa could be demonstrated via pathological analysis, such as, engorgement, thickening, decurtation, denudation and so on. Conclusion After cerebral arterial thrombosis, damages of intestinal mucosa and intestinal dyskinesis may occur, the above two may be cause and effect for each other.

Key words: middle cerebral artery occlusion(MCAO), intestinal motility, intestinal mucosa