非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者的鼻通气功能评估

首都医科大学学报 ›› 2011, Vol. 32 ›› Issue (1): 26-31.

• 耳鼻咽喉头颈外科基础与临床研究 • 上一篇下一篇

非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者的鼻通气功能评估

杨酉¹，刘仲燕²，韩德民^1，2，张罗^1，2*

1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科； 2. 教育部耳鼻咽喉头颈外科重点实验室，北京市耳鼻咽喉科研究所

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-21 发布日期:2011-02-21
通讯作者: 张罗

Assessment of Nasal Ventilation Function of Nonallergic Rhinitis withEosinophilia Syndrome

YANG You¹, LIU Zhong-yan², HAN De-min^1,2, ZHANG Luo^1,2*

1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University; 2. Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology

Received:1900-01-01 Revised:1900-01-01 Online:2011-02-21 Published:2011-02-21
Contact: ZHANG Luo

摘要/Abstract

摘要：

目的本文检测非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者（nonallergic rhinitis with eosinophilia syndrome，NARES）的鼻通气功能，分析其与主观症状的相关性。
方法 NARES患者22例，健康成人58例。测量鼻阻力获得压力-流速曲线，得到75 Pa和150 Pa下鼻腔总阻力值。测量使用1%麻黄碱滴鼻液前后鼻腔的鼻声反射，获得相应的面积-距离曲线，得到鼻腔最小横截面积，计算鼻腔充血指数。分析非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者症状评分与鼻通气功能指标间的相关性；对比NARES组与对照组鼻阻力和鼻声反射测量各项指标。
结果 ① NARES患者鼻阻力、鼻声反射指标与各鼻部症状间的相关性分析差异均无统计学意义；② 鼻声反射仪测量收缩前后的鼻腔最小横截面积以及鼻腔充血指数，NARES组与正常对照组相比差异无统计学意义；③ NARES组与正常对照组相比，收缩前75 Pa和150 Pa下鼻总阻力值差异有统计学意义，收缩后75 Pa和150 Pa下的鼻总阻力值差异无统计学意义。
结论 NARES患者主观症状与客观鼻生理功能检测结果间无相关性，在诊疗过程中需全面综合评价患者的主观症状和客观检测结果。

关键词: 非过敏性鼻炎嗜酸性粒细胞增多综合征, 主观症状评估, 鼻阻力, 鼻声反射, 鼻分泌物涂片

Abstract:

Objective To measure the nasal patency of patients with nonallergic rhinitis with eosinophilia syndrome(NARES) and healthy controls and to assess its correlation with visual analogue scale(VAS) of nasal symptom.
Methods A total of 22 patients with NARES and 58 healthy controls were studied. By using nasal rhinomanometry, we measured the pressure-flow curve and got total nasal resistances of 75 Pa and 150 Pa. By means of acoustic rhinometry, we obtained the area-distance curve before and after using nasal vasoconstrictive agent, got the nasal minimum cross-sectional area(MCA), then calculated nasal congestion index(NCI). We compared the outcomes with nasal resistance and acoustic rhinometry in two groups, evaluated the correlation between VAS and nasal patency of NARES.
Results The correlation between the outcomes with nasal resistance and acoustic rhinometry and VAS of nasal symptom showed no statistical significance in NARES patients. MCA before and after decongestion and NCI showed no statistically significant differences in two groups. Before decongestion, nasal resistance of 75 Pa and 150 Pa had significant differences in two groups, after decongestion showed no significant difference.
Conclusion Nonallergic rhinitis with eosinophilia syndrome is one of the most common nonallergic rhinitis, subjective symptoms had no correlation with objective nasal patency tests. In clinic, it required comprehensive evaluation with subjective symptoms and objective test results of patient.

Key words: nonallergic rhinitis with eosinophilia syndrome, visual sanalogue scale, nasal resistance, acoustic rhinometry, nasal secretion mear

中图分类号:

R 765.2

杨酉;刘仲燕;韩德民;张罗. 非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者的鼻通气功能评估[J]. 首都医科大学学报, 2011, 32(1): 26-31.

YANG You;LIU Zhong-yan;HAN De-min;ZHANG Luo;. Assessment of Nasal Ventilation Function of Nonallergic Rhinitis withEosinophilia Syndrome[J]. Journal of Capital Medical University, 2011, 32(1): 26-31.

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[2]	张伟;张罗. 鼻通气功能客观评价[J]. 首都医科大学学报, 2012, 33(6): 740-744.
[3]	曹春婷;漆可;王睿韬;张罗. 麻黄素对鼻腔通气功能的影响[J]. 首都医科大学学报, 2011, 32(6): 746-749.
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非过敏性鼻炎伴嗜酸性粒细胞增多综合征患者的鼻通气功能评估

Assessment of Nasal Ventilation Function of Nonallergic Rhinitis withEosinophilia Syndrome

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