慢性丙型肝炎患者DNT细胞及T细胞亚群的研究

doi:10.3969/j.issn.1006-7795.2012.02.016

首都医科大学学报 ›› 2012, Vol. 33 ›› Issue (2): 214-217.doi: 10.3969/j.issn.1006-7795.2012.02.016

慢性丙型肝炎患者DNT细胞及T细胞亚群的研究

梁骑¹, 焦艳梅², 计云霞², 李田², 吴昊², 张国元¹, 唐中¹

1. 川北医学院附属医院检验科,南充 637100;2. 首都医科大学附属北京佑安医院感染科,北京100069

收稿日期:2011-11-25 修回日期:1900-01-01 出版日期:2012-04-21 发布日期:2012-04-21
通讯作者: 唐中

Double negative T cells and lymphocyte subtype in chronic hepatitis C

LIANG Qi¹, JIAO Yan-mei², JI Yun-xia², LI Tian², WU Hao², ZHANG Guo-yuan¹, TANG Zhong¹

1. Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637100, China;2. Department of Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China

Received:2011-11-25 Revised:1900-01-01 Online:2012-04-21 Published:2012-04-21

摘要/Abstract

摘要： 目的探讨外周血中CD3⁺CD4^-CD8^-(double negative T,DNT)细胞及T淋巴细胞亚群在慢性丙型肝炎(chronic hepatitis C,CHC)患者中的表达及意义。方法利用流式细胞仪对92例CHC患者、93例正常健康人外周血中的DNT细胞及T细胞亚群进行检测,并对比分析两者的差异。结果 CHC患者DNT细胞百分比(8.57%±6.16%)高于正常对照组(6.78%±4.50%)(P<0.05),其绝对数在两者间比较,差异无统计学意义(P>0.05)。CHC患者CD4⁺%,CD4⁺/ CD8⁺比值低于正常对照组(P值均<0.001),CD8⁺%高于正常对照组(P<0.001)。结论 CHC患者DNT细胞百分比显著升高及T淋巴细胞亚群比例改变,可能是丙型肝炎病毒感染慢性化的重要原因之一。

关键词: 慢性丙型肝炎, DNT细胞, T淋巴细胞亚群

Abstract: Objective To investigate the expression and significance of CD3⁺CD4^-CD8^-(double negative T, DNT) cells and T lymphocyte subsets in chronic hepatitis C cases. Methods DNT cells and lymphocyte subsets of peripheral blood were detected by flow cytometry in 92 chronic hepatitis C patients and 93 healthy people, the differences between them was comparatively analyzed. Results The percent of DNT cells(8.57%±6.16%) were higher in patients with chronic hepatitis C than those in normal control group(6.78%±4.50%)(P<0.05), However, there was no significant difference in the absolute value of DNT cells between them(P>0.05). The CD4 cells, the ratio of CD4⁺/CD8⁺ were decreased but CD8 cells increased in comparison with normal control group(P<0.001). Conclusion The significant increase of DNT cells and the change of T lymphocyte subsets's percentage in chronic hepatitis C patients might be one of the important reason for chronicity and long-term liver damage of hepatitis C.

Key words: chronic hepatitis C, double negative T cell, T lymphocyte subsets

中图分类号:

R 512.6⁺3

梁骑;焦艳梅;计云霞;李田;吴昊;张国元;唐中. 慢性丙型肝炎患者DNT细胞及T细胞亚群的研究[J]. 首都医科大学学报, 2012, 33(2): 214-217.

LIANG Qi;JIAO Yan-mei;JI Yun-xia;LI Tian;WU Hao;ZHANG Guo-yuan;TANG Zhong. Double negative T cells and lymphocyte subtype in chronic hepatitis C[J]. Journal of Capital Medical University, 2012, 33(2): 214-217.

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慢性丙型肝炎患者DNT细胞及T细胞亚群的研究

Double negative T cells and lymphocyte subtype in chronic hepatitis C

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