ApoEε4基因结合sMRI对不同亚型轻度认知功能障碍的研究

doi:10.3969/j.issn.1006-7795.2017.01.012

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (1): 59-62.doi: 10.3969/j.issn.1006-7795.2017.01.012

• 脑血管病、认知障碍的基础及临床研究 • 上一篇下一篇

ApoEε4基因结合sMRI对不同亚型轻度认知功能障碍的研究

马隽^1,2, 王朝辉³, 谷雪松¹, 满凤媛⁴

1. 北华大学附属医院放射科, 吉林吉林 132011;
2. 首都医科大学附属北京友谊医院放射科, 北京 100050;
3. 北华大学附属医院神经内科, 吉林吉林 132011;
4. 中国人民解放军火箭军总医院医学影像科, 北京 100088

收稿日期:2016-11-28 出版日期:2017-01-21 发布日期:2017-01-20
通讯作者: 满凤媛 E-mail:13159543160@163.com
基金资助:
吉林省教育厅基金资助[2011]144号。

Study of ApoEε4 gene combined with sMRI in mild cognitive impairment

Ma Jun^1,2, Wang Zhaohui³, Gu Xuesong¹, Man Fengyuan⁴

1. Department of Radiology, Hospital of Beihua University, Jilin 132011, Jilin Province, China;
2. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
3. Department of Neurology, Hospital of Beihua University, Jilin 132011, Jilin Province, China;
4. Department of Radiology, The General Hospital of the PLA Rocket Force, Beijing 100088, China

Received:2016-11-28 Online:2017-01-21 Published:2017-01-20
Supported by:
This study was supported by Jilin Provincial Department of Education Funding[2011] 144.

摘要/Abstract

摘要： 目的评价4种不同轻度认知障碍亚型之间人口统计学、心理特点、结构性磁共振成像（structural magnetic resonance imaging，sMRI）及载脂蛋白Eε4（apolipoprotein Eε4，ApoEε4）的特点。方法对94例轻度认知障碍的老年人，与53例认知程度正常老年人作为对照组进行评价。4种轻度认知障碍（mild cognitive impairment，MCI）基于神经心理学表现分类，颞叶内侧面萎缩（medial temporal lobe atrophy，MTA）和脑白质高信号（white matter hyperintensity，WMH）通过sMRI评估。另外，研究简易精神状态检查表（Minimum Mental State Examination，MMSE）评分、MTA评分、WMH和MCI亚型间与ApoEε4关系。通过sMRI评估。结果在不同亚型的MCI及对照组之间其MMSE评分、MTA差异有统计学意义，遗忘型轻度认知障碍（amnestic MCI，aMCI）亚型与非遗忘型轻度认知障碍亚型（non-amnestic MCI，naMCI）相比，MTA评分明显增加。然而，WMH无明显差异。ApoEε4基因在aMCI及naMCI亚型中显著增加。结论 MCI不同亚型可显示生物异质性，sMRI结合ApoEε4可以协同预测MCI向痴呆的发展。

关键词: 轻度认知障碍, 临床分型, 结构磁共振成像, 颞叶内侧面萎缩, 载脂蛋白Eε4基因, 脑白质高信号

Abstract: Objective To evaluate demographics, neuropsychological performance, structural magnetic resonance imaging (sMRI) measures, and apolipoprotein E genotype among four mild cognitive impairment (MCI) subtypes. Methods A total of 94 subjects with MCI and 53 cognitively normal older participants (controls) were evaluated. Classification of subjects with MCI into four subtypes based on neuropsychological performance, were investigated about sMRI research and ApoEε4 genotype. Medial temporal lobe atrophy (MTA) and prevalence of white matter hyperintensity (WMH) were assessed by sMRI. In addition, to study the relationship between Minimum Mental State Examination (MMSE) score, MTA score and ApoEε4 score, WMH and MCI subtypes. Results Severity of MMSE and MTA differed among MCI subtypes and control group. We found that 2 amnestic forms of MCI patients had significantly higher MTA scores than the 2 nonamnestic forms of MCI patients. However, there are not significant differences in WMH among the MCI subtypes. Apolipoprotein E genotype prevalence was significantly higher in the amnestic compared with nonamnestic subtypes of MCI. In addition, in amnestic MCI-single domain (aMCI-SD) and amnestic MCI-multiple domain (aMCI-MD) subjects, presence of ApoEε4 allele had a significant impact on the severity of MTA and memory deficits. Conclusion The different subtypes of MCI, may display biological heterogeneity, suggesting that sMRI in combination with the ApoEε4 genotype might be more helpful to predict progression from MCI to dementia.

Key words: mild cognitive impairment, clinical subtypes, structural magnetic resonance imaging, medial temporal lobe atrophy, apolipoprotein Eε4 genotype, white matter hyperintensity

中图分类号:

R741

马隽, 王朝辉, 谷雪松, 满凤媛. ApoEε4基因结合sMRI对不同亚型轻度认知功能障碍的研究[J]. 首都医科大学学报, 2017, 38(1): 59-62.

Ma Jun, Wang Zhaohui, Gu Xuesong, Man Fengyuan. Study of ApoEε4 gene combined with sMRI in mild cognitive impairment[J]. Journal of Capital Medical University, 2017, 38(1): 59-62.

参考文献

[1] Petersen R C, Smith G E, Waring S C, et al. Mild cognitive impairment:clinical characterization and outcome[J]. Arch Neurol, 1999,56(3):303-308.
[2] Vlooswijk M C, Jansen J F,de Krom M C, et al. Functional MRI in chronic epilepsy:associations with cognitive impairment[J]. Lancet Neurol, 2010, 9(10):7018-7022.
[3] Corder E H, Saunders A M, Strittmatter W J,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families[J].Science,1993, 261(5123):921-923.
[4] Amercian Psychiatric Association. The diagnosic and statisitical manual of menual of mental disorders(DSM-4)[M].Arlington:APA,2008:47.
[5] Folstein M F,Folstein S E,Mchugh P R."Mini-mental state":a practical method for grading the cognitive state of patients for the clinician[J].J Psychiatr Res,1975,12(3):189-198
[6] Lawton M P,Brody M P.Assesment of older people:self-maintaining and instrumental activities of daily living[J].Gerontologist,1969,9(3):179-186.
[7] Jack C R Jr, Shiung M M, Weigand S D, et al. Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI[J]. Neurology, 2005,65(8):1227-1231.
[8] Mariani E, Monastero R, Ercolani S, et al. Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project[J]. Dement Geriatr Cogn Disord, 2007,24(6):448-456.
[9] Cherbuin N, Leach L S, Christensen H, et al. Neuroimaging and ApoE genotype:a systematic qualitative review[J]. Dement Geriatr Cogn Disord, 2007, 24(5):348-362.
[10] Portet F,Ousset P J,Visser P J,et al.Mild cognitive impairment (MCI) in medical practice:acritical review of the concept and new diagnostic procedure.Report of the MCI working Group of the European Consortium on Alzheimeris DiSEASE[J].J Neurol Neurosurg Psychiatry,2006,77(6):714-718.
[11] Dubois B,Feldman H H,Jacova C,et al.Research criteria for the diagnosis of Alzheimer's disease:revising the NINCDS-ADRDA criteria[J].Lancet Neurol,2007,6(8):734-746.
[12] Rémy F, Mirrashed F, Campbell B, et al. Verbal episodic memory impairment in Alzheimer's disease:a combined structural and functional MRI study. Neuroimage, 2005,25(1):253-266.
[13] Granziera C,Hadjikhani N,Arzy S,et al.In-vivo magnetic resonance imaging of the structuctural core of the Papez circuit in humans[J].Neuroreport,2011,22(5):227-231.
[14] Pereira J B, Cavallin L. Spulber G. et al. Influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs[J].Intern Medi. 2014, 275(3); 317-330.

ApoEε4基因结合sMRI对不同亚型轻度认知功能障碍的研究

Study of ApoEε4 gene combined with sMRI in mild cognitive impairment

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价

[1]	李琼, 赵建华, 刘昊, 王凡, 李青, 陈希妍, 蔡瑞艳, 吴清武, 张健, 吉四辈, 路承彪, 李少敏. 脑白质高信号患者血清CX3CL1水平与认知功能障碍的关系[J]. 首都医科大学学报, 2023, 44(1): 6-12.
[2]	董力, 马茜, 吕晓艳, 殷小平, 杨雯, 王晓东, 边伟林. 不同临床分型的新型冠状病毒肺炎患者影像学表现[J]. 首都医科大学学报, 2020, 41(2): 283-289.
[3]	樊响, 杨延辉, 贾秀琴, 卢洁, 李坤成. 轻度认知障碍静息态功能磁共振研究低频振幅分析[J]. 首都医科大学学报, 2018, 39(2): 163-166.
[4]	贾建平. 痴呆与轻度认知障碍的流行病学、发病机制和诊治应用研究——2013年度国家科学技术进步二等奖[J]. 首都医科大学学报, 2014, 35(1): 1-5.