视网膜分支静脉阻塞与颈内动脉弹性功能参数相关性研究

doi:10.3969/j.issn.1006-7795.2017.01.002

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (1): 6-10.doi: 10.3969/j.issn.1006-7795.2017.01.002

视网膜分支静脉阻塞与颈内动脉弹性功能参数相关性研究

李爽, 王薇, 洪慧, 赵露, 王艳玲

首都医科大学附属北京友谊医院眼科, 北京 100050

收稿日期:2016-09-10 出版日期:2017-01-21 发布日期:2017-01-20
通讯作者: 王艳玲 E-mail:wangyanling999@vip.sina.com
基金资助:
国家自然科学基金（81173412），北京市自然科学基金（7122046）。

Relationship between branch retinal vein occlusion and internal carotid artery elasticity

Li Shuang, Wang Wei, Hong Hui, Zhao Lu, Wang yanling

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2016-09-10 Online:2017-01-21 Published:2017-01-20
Supported by:
This study was supported by National Natural Science Foundation of China (81173412),Natural Science Foundation of Beijing(7122046).

摘要/Abstract

摘要： 目的探讨视网膜分支静脉阻塞与颈内动脉狭窄及颈内动脉弹性功能参数的相关性。方法选择2014年1月至2014年11月在首都医科大学附属北京友谊医院眼科确诊为视网膜分支静脉阻塞病人56例（56眼）作为研究组，对照组选取无视网膜分支静脉阻塞者36例（36眼），均进行多普勒彩超检查，测定颈内动脉的收缩期内径（systolic diameter，Ds）、舒张期内径（diastolic diameter，Dd）、收缩期血流峰值（peak systolic velocity，Vs）、舒张期血流峰值（end diastolic velocity，Vd）、平均血流速度（mean velocity，Vm）、内-中膜厚度（intima-media thickness，IMT）、斑块形成情况，计算颈内动脉弹性功能参数：管壁运动度（wall motion degree，ΔD）、动脉紧张度、扩张性、压力-应变性系数（pressure-strain elastic modulus，Eρ）、僵硬度指数（stiffness index，β）、顺应性（arterial compliance，AC）、阻力指数（resistance index，RI），将2组各指标进行比较分析。结果颈动脉斑块、颈内动脉狭窄发生比例及颈内动脉的IMT等指标，研究组明显高于对照组（P<0.05）。颈内动脉管壁运动度（ΔD）、动脉紧张度、动脉扩张性、压力-应变性系数（Eρ）及顺应性（AC）等指标，研究组与对照组比较，差异具有统计学意义（P<0.05）。研究组的平均血流速度（Vm）、阻力指数（RI）及僵硬度指数（β）与对照组比较，差异无统计学意义（P>0.05）。结论视网膜分支静脉阻塞的发生与颈内动脉狭窄及颈内动脉弹性功能参数的改变有一定的相关性。

关键词: 视网膜分支静脉阻塞, 颈内动脉, 动脉弹性指标

Abstract: Objective To investigate the relationship between BRVO (branch retinal vein occlusion) and internal carotid artery elasticity. Methods For patients with BRVO who presented to Beijing Friendship Hospital between January 2014 and November 2014, 92 eyes of 92 patients were assigned as the participants,56 patients with BRVO were assigned as the BRVO group,36 patients were enrolled as control.All the participants were examined with color Doppler ultrasonography, these indexes were systolic diameter(Ds),diastolic diameter(Dd), peak systolic velocity(Vs), end diastolic velocity(Vd),mean velocity(Vm),intima-media thickness(IMT) and plaque formation.These values were calculated:the internal carotid artery elastic parameters by relevant formula; wall motion degree(ΔD),arterial tension,arterial expansion,pressure-strain elastic modulus(Eρ),stiffness index(β),arterial compliance(AC)and resistance index(RI), internal carotid artery elasticity parameters and other index.Results Carotid plaque detection rate,internal carotid artery stenosis rate and intima-media thickness(IMT)of BRVO group were significantly higher than those of control group(P<0.05),wall motion degree(ΔD),arterial tension,arterial expansion,pressure-strain elastic modulus(Eρ),and arterial compliance(AC)of BRVO group had significant differences compared with control group(P<0.05), resistance index(RI), mean velocity(Vm) and stiffness index (β) of BRVO group have no significant differences compared with control group(P>0.05).Conclusion The detection of carotid artery hemodynamic parameters for patients with branch retinal vein occlusion is important, there is a relationship between BRVO and internal carotid artery elasticity.

Key words: branch retinal vein occlusion, internal carotid artery, artery elasticity parameter

中图分类号:

R543.4
R774

李爽, 王薇, 洪慧, 赵露, 王艳玲. 视网膜分支静脉阻塞与颈内动脉弹性功能参数相关性研究[J]. 首都医科大学学报, 2017, 38(1): 6-10.

Li Shuang, Wang Wei, Hong Hui, Zhao Lu, Wang yanling. Relationship between branch retinal vein occlusion and internal carotid artery elasticity[J]. Journal of Capital Medical University, 2017, 38(1): 6-10.

参考文献

[1] Leone N,Ducimetiere P, Gariepy J,et al. Distension of the carotid artery and risk of coronary events:the three city study[J].Arterionscler Thromb Vasc Biol,2008,28(7):1392-1397.
[2] Dingzhu S,Sanli X,Chuan C, et al. Effect of Shoushen granule on arterial elasticity in patients with carotid atherosclerosis:a clinical randomized controlled trial[J].J Tradit Chin Med,2015,35(4):389-395.
[3] Wantanabe S,Okura T,Kitami Y,et al. Carotid hemodynamic alterations in hypertensive patients with insulin resistance[J].Am J Hypertens, 2002,15(10 Pt 1):851-856.
[4] Shau Y W, Wang C L, Shieh J Y, et al. Noninvasive assessment of the viscoelasticity of peripheral arteries[J].Ultrasound Med Biol,1999,25(9):1377-1388.
[5] Luo Z, Wang Y, Wang W. Estimating coronary artery lumen area with optimization-based contour detection[J]. IEEE Trans Med Imaging, 2003,22(4),564-566.
[6] Haller J A, Bandello F, Belfort R Jr, et al. Randomized,sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion[J].Ophthalmology, 2010, 117(6):1134-1146.
[7] Rogers S, Mclntosh R L, Cheung N, et al. The prevalence of retinalvein occlusion:pooled data from population studies from the United States, Europe, Asia and Australia[J]. Ophthalmology, 2010,117(2):313-319.
[8] Panakanti T K, Chhablani J. Clinical trials in branch retinal vein occlusion[J].Middle East Afr J Ophthalmol,2016,23(1):38-43.
[9] Jonas J B. Medical therapy for macular edema secondary to retinal vein occlusion[J].Asia Pac J Ophthalmol(phila),2016,5(2):93-94.
[10] Chiquet C, Bron A M, Straub M, et al. Retinal vein occlusions:therapeutic switch in macular edema treatment with a 12-month follow-up[J].Ophthalmic Res,2016,55(3):152-158.
[11] Bruno A, Russell P W, Jones W L, et al. Concomitants of asymptomatic retinal cholesterol emboli[J]. Stroke, 1992, 23(6):900-902.
[12] Lyons-Wait V A, Anderson S F, Townsend J C, et al. Ocular and systemic findings and their correlation with hemodynamically significant carotid artery stenosis:a retrospective study[J]. Optom Vis Sci, 2002, 79(6):353-362.
[13] Chawluk J B, Kushner M J, Bank W J, et al. Atherosclerotic carotid artery disease in patients with retinal ischemic syndromes[J]. Neurology,1988, 38(6):858-863.
[14] van Popele N M,Grobbee D E, Bots M L,et al. Association between arterial stiffiness and atherosclerosis:the Rotterdam Study[J].Stroke,2001,32(2):454-460.
[15] Zou C, Jiao Y, Li X, et al. Role of ultrasonography in the evaluation of correlation between strain and elasticity of common carotid artery in patients with diabetic nephropathy[J].Int J Clin Exp Med, 2015, 8(10):17765-17772.
[16] Palombo G,Stella N,Fantozzi C,et al.Transcranial Doppler and diffusion-weighted magnetic resonance evaluation of cerebral embolization occurring during transfemoral carotid stenting with proximal flow blockage[J]. J Cardiovasc Surg, 2016, 57(1):52-57.
[17] Krishnamoorthy P, Patil R B, Ravi V. Temporal and spectral analysis of internal carotid artery Doppler signal for normal and abnormal flow detection[J]. Conf Proc IEEE Eng Med Biol Soc,2015,2015:6122-6125.

视网膜分支静脉阻塞与颈内动脉弹性功能参数相关性研究

Relationship between branch retinal vein occlusion and internal carotid artery elasticity

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

本文评价

[1]	宁彬, 张东, 王立淑, 金金, 甘雨洋, 宋海曼, 于腾飞, 何文. 颈动脉蹼的超声表现多样性与病理对照研究[J]. 首都医科大学学报, 2019, 40(6): 824-828.
[2]	许晴, 刘丽娜, 宋妍婷, 曲爱娟. 超声二维斑点追踪技术分析小鼠颈动脉僵硬度的方法学研究[J]. 首都医科大学学报, 2018, 39(6): 883-888.
[3]	杨敏京, 张永辉, 刘洁琳, 毕齐, 王以新. 社区中老年人群颈动脉粥样硬化影响因素分析[J]. 首都医科大学学报, 2013, 34(6): 868-871.