关键词: 高压氧, 烟雾病, 成人, 脑梗死, 脑出血, 预后

Abstract: Objective To investigate the application of hyperbaric oxygen therapy(HBOT) on moyamoya disease in adult patients. Methods The consecutive adult patients with Moyamoya disease admitted in the Department of Hyperbaric oxygen, Fuxing Hospital,Capital Medical University from March 2009 to December 2016 were enrolled. The clinical features, effect after HBOT and cerebrovascular events during HBOT were analyzed. The clinical follow-up duration was 3 months. The National Institutes of Health Stroke Scale (NIHSS) was used to score neurological deficit. The Modified Rankin Scale (mRS) was used to score the prognosis of patients. Results A total of 13 adult patients with moyamoya disease were enrolled into this retrospective study, including 8 cases of ischemic lesion and 5 cases of hemorrhage lesion. In patients with ischemic lesion, 4 patients were bilateral hemispheres involvement and 4 patients were unilateral involvement, 5 patients were treated with revascularization surgery and complicated with cerebral infarction. In patients with hemorrhage lesion, 3 patients showed ventricle hemorrhage, 2 patients showed cerebral hemorrhage broken into ventricles, and all these patients were treated with evacuation of hematoma/or ventriculopuncture. The neurological deficit scores of all patients were poor before hyperbaric oxygen therapy. The number of HBOT ranged from 5 to 40 sessions. The clinical symptoms of 12 patients were improved after HBOT, 1 patient was invalid, 2 patient re-showed cerebral infarction during HBOT, 10 patients had good prognosis at 3 months(mRS ≤ 3). Conclusion HBOT can effectively reduce the postoperative symptoms of moyamoya disease in adult patients and improve prognosis at 90th days, meanwhile HBOT does not significantly increase the occurrence of cerebrovascular events.

Key words: hyperbaric oxygen therapy, moyamoya disease, adult, cerebral infarction, cerebral hematoma, progonosis