应用磁共振4D flow成像对正常颅内前循环动脉血流动力学参数定量评估的可重复性研究

doi:10.3969/j.issn.1006-7795.2018.02.001

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (2): 157-162.doi: 10.3969/j.issn.1006-7795.2018.02.001

• 影像新技术的临床与科研应用 • 上一篇下一篇

应用磁共振4D flow成像对正常颅内前循环动脉血流动力学参数定量评估的可重复性研究

隋滨滨¹, 高培毅¹, 林燕¹, 赵海清², 宋立刚³

1. 首都医科大学附属北京天坛医院放射科磁共振成像脑信息学北京市重点实验室, 北京 100050;
2. 清华大学附属垂杨柳医院放射科, 北京 100021;
3. 首都医科大学附属北京天坛医院介入神经病科, 北京 100050

收稿日期:2018-02-27 出版日期:2018-03-21 发布日期:2018-04-14
通讯作者: 高培毅 E-mail:cjr.likuncheng@vip.163.com
基金资助:
国家自然科学基金（81471649），北京市科技重大专项（Z171100000117001），北京市医院管理局重点医学专业发展计划（ZYLX201609）。

Reproducibility of quantitative flow assessment of intracranial arteries of anterior cerebral circulation of healthy subjects using 4D flow imaging

Sui Binbin¹, Gao Peiyi¹, Lin Yan¹, Zhao Haiqing², Song Ligang³

1. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing Key Laboratory of MRI and Brain Informatics, Beijing 100050, China;
2. Department of Radiology, Chui Yang Liu Hospital Affiliated to Tsinghua University, Beijing 100021, China;
3. Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

Received:2018-02-27 Online:2018-03-21 Published:2018-04-14
Supported by:
This study was supported by National Natural Science Foundation of China(81471649), Science and Technology Major Project of Beijing(Z171100000117001), Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support(ZYLX201609).

摘要/Abstract

摘要： 目的探讨应用磁共振4D flow成像对正常颅内前循环动脉的血流动力学状态进行定量评估的可重复性。方法收集正常志愿者4例，对每名志愿者的颅内Willis环区域分别进行两次4D flow成像，应用4D flow图像后处理软件测量计算正常志愿者双侧颈内动脉（internal carotid artery，ICA）入颅段、虹吸段、末端、双侧大脑中动脉（middle cerebral artery，MCA）起始部及近段、大脑前动脉（anterior cerebral artery，ACA）起始部（每例取双侧共12个位置）的血流动力学参数，比较两次扫描的平均血管面积、平均及最大血流速度、平均及最大瞬时血流量。生成血流矢量图、流线图及粒子追踪图显示颅内前循环大动脉的血流动力学状态。结果 4名正常志愿者两次颅内Willis环血流参数比较显示，ICA虹吸段左侧最大血流速度及右侧各项血流动力学参数两次扫描之间的差异有统计学意义；ICA入颅段、MCA及ACA起始部双侧及MCA近段右侧最大血流速度之间的差异有统计学意义；MCA近段双侧平均血管面积、ACA起始部左侧平均血管面积及平均血流速度之间的差异有统计学意义。其中一名志愿者的心率两次之间有较大变化，两次的最大血流速度之间存在明显区别。另外，在针对不同部位的分析中发现，颈动脉虹吸段位置两次测量的最大血流速度之间存在较明显区别。结论应用磁共振4D flow成像对颅内动脉血流速度的评估的可重复性较好，对于不同心率状态下以及血流状态复杂部位的血流动力学评估，4D flow成像测量的可重复性可能还需要进一步验证。

关键词: 磁共振成像, 颅内动脉, 血流动力学, 4D血流成像, 可重复性

Abstract: Objective To investigate the reproducibility of quantitative flow assessment of healthy subjects using 4D flow imaging. Methods Four healthy volunteers were enrolled in this study. Four-dimensional flow magnetic resonance (MR) imaging were acquired and rescanned for circle of Willis using the same protocol and parameters. The flow data were post-processed with a prototype flow analysis software 4D Flow. The hemodynamic parameters at the biateral locations including the inlet of the intracranial portion of the internal carotid artery (ICA), the siphon of the ICA, the distal segment of the ICA, the beginning and the proximal segment of the middle cerebral artery (MCA), and the proximal segment of the anterior cerebral artery (ACA) were calculated. The average vessel area, average velocity, maximum flow velocity, and average net flow rate obtained from the first imaging and rescanned imaging were compared. Velocity vectors, streamlines, and particle traces maps were visualized. Results The comparison of hemodynamic parameters showed that significant difference was found in all parameters of right ICA (RICA) siphon, the maximum flow velocity of left ICA (LICA) siphon, bilateral ICA inlet segment, the beginning of bilateral MCA and ACA, and the proximal segment of right MCA, as well as the average area of the proximal segment of bilateral MCA and the beginning of left ACA, and the average velocity of the beginning of left ACA between two scanned images. In one subject, the heartbeats of two scans showed obvious change; and the maximum flow velocity was found to vary obviously. In the siphon segment of ICA, it was also found that there was intense variety in maximum flow velocity between two examinations. Conclusion The reproducibility of 4D flow imaging in quantitative flow assessment of intracranial arteries was acceptable. However, the reproducibility of 4D flow imaging will need further confirmation under different heartbeats conditions and for locations with complex hemodynamics status in future studies.

Key words: magnetic resonance imaging, intracranial arteries, hemodynamics, 4D flow imaging, reproducibility

中图分类号:

R445

隋滨滨, 高培毅, 林燕, 赵海清, 宋立刚. 应用磁共振4D flow成像对正常颅内前循环动脉血流动力学参数定量评估的可重复性研究[J]. 首都医科大学学报, 2018, 39(2): 157-162.

Sui Binbin, Gao Peiyi, Lin Yan, Zhao Haiqing, Song Ligang. Reproducibility of quantitative flow assessment of intracranial arteries of anterior cerebral circulation of healthy subjects using 4D flow imaging[J]. Journal of Capital Medical University, 2018, 39(2): 157-162.

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应用磁共振4D flow成像对正常颅内前循环动脉血流动力学参数定量评估的可重复性研究

Reproducibility of quantitative flow assessment of intracranial arteries of anterior cerebral circulation of healthy subjects using 4D flow imaging

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