光动力疗法联合冷冻治疗尖锐湿疣的临床效果

doi:10.3969/j.issn.1006-7795.2021.05.026

摘要/Abstract

摘要： 目的针对光动力疗法联合冷冻治疗尖锐湿疣的临床效果进行探讨与研究。方法 100例成年尖锐湿疣患者采用数字表法随机分为两组,对照组采用光动力疗法,观察组采用光动力疗法联合液氮冷冻,对比治疗前后的总有效率、复发率、不良发生率、疣体清除率以及21种人类乳头瘤病毒(human papilloma virus,HPV)基因分布。结果观察组总有效率为96%,复发率为6%,不良反应发生率为10%;对照组总有效率为90%,复发率为26%,不良反应发生率为38%,治疗后,观察组疣体直径短于对照组,两组差异有统计学意义(P<0.05)。结论相对单一应用光动力疗法,光动力联合液氮冷冻治疗尖锐湿疣治疗效果显著,治疗有效率高、疣体清除率高,复发率及不良反应率低,值得在临床中推广。

关键词: 光动力疗法, 液氮冷冻, 尖锐湿疣, 临床效果

Abstract: Objective To discuss and study the clinical effect of photodynamic therapy combined with liquid nitrogen cryotherapy on the treatment of condyloma acuminatum. Methods Totally 100 adult patients with condyloma acuminatum were randomly divided into two groups. The control group was treated with photodynamic therapy, and the observation group was treated with photodynamic therapy combined with liquid nitrogen freezing. The total effective rate, recurrence rate, adverse incidence rate, and wart removal before and after treatment were compared. Rate and the distribution of 21 HPV genes. Results The total effective rate of the observation group was 96%, the recurrence rate was 6%, and the incidence of adverse reactions was 10%; the total effective rate of the control group was 90%, the recurrence rate was 26%, and the incidence of adverse reactions was 38%. After treatment, the diameter of warts in the observation group shorter than the control group, the difference between the two groups is statistically significant (P<0.05). Conclusion Compared with the single application of photodynamic therapy, photodynamic combined with liquid nitrogen cryotherapy has a significant effect on the treatment of condyloma acuminatum, with high treatment efficiency, high wart clearance rate, low recurrence rate and adverse reaction rate, and it is worthy of clinical promotion.

Key words: photodynamic therapy, liquid nitrogen freezing, condyloma acuminatum, clinical effect

中图分类号:

R752.5

崔羽立. 光动力疗法联合冷冻治疗尖锐湿疣的临床效果[J]. 首都医科大学学报, 2021, 42(5): 857-861.

Cui Yuli. Clinical effect of photodynamic therapy combined with liquid nitrogen freezing on the treatment of condyloma acuminatum[J]. Journal of Capital Medical University, 2021, 42(5): 857-861.

参考文献

[1] 顾丽群, 任祺, 朱周,等. CO₂激光联合5-氨基酮戊酸光动力疗法治疗难治性尖锐湿疣的临床研究[J]. 中国性科学, 2019,28(4):144-147.
[2] Furukawa S, Uota S, Yamana T, et al. Distribution of human papillomavirus genotype in anal condyloma acuminatum among japanese men: the higher prevalence of high risk human papillomavirus in men who have sex with men with HIV infection[J]. AIDS Res Hum Retrovir, 2018,34(4):375-381.
[3] 邵勇,翟俊莎.光动力与尤靖安联合治疗多发性尖锐湿疣临床疗效及其对性生活质量的影响[J].中国性科学,2019,28(3):127-130.
[4] Hu Y E, Dai S F, Wang B, et al. Therapeutic effects of topical 5-aminolevulinic acid photodynamic therapy [J]. Pak J Med Sci, 2016, 32(4):961-964.
[5] 李小群,胡立明,陈国菊,等.盐酸氨酮戊酸散光动力疗法治疗尖锐湿疣的临床疗效分析[J].中国性科学,2018,27(11):125-128.
[6] 吴伟棋,杨娟,卢秀仪,等.5-氨基酮戊酸光动力疗法治疗尖锐湿疣患者的疗效观察[J].实用中西医结合临床,2020,20(7):4-5,35.
[7] Mistrangelo M, Dal Conte I, Volpatto S, et al. Current treatments for anal condylomata acuminata[J]. Minerva Chir,2018,73(1):100-106.
[8] 俞利青.5-氨基酮戊酸-光动力疗法治疗尖锐湿疣的效果分析[J].北京医学,2020,42(7):686-687.
[9] Widschwendter A, Böttcher B, Riedl D, et al. Recurrence of genitals warts in pre-HPV vaccine era after laser treatment[J]. Arch Gynecol Obstet, 2019,300(3):661-668.
[10]Zhao W, Shan X F, Wang C L, et al. Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts[J]. J Dermatolog Treat,2020,31(3):241-244.
[11]吴洪波. 5-氨基酮戊酸光动力疗法与液氮冷冻疗法治疗尖锐湿疣的临床效果[J]. 临床医学研究与实践, 2019, 4(25):69-70.
[12]Xie J, Ao C, Li J, et al. 5-aminolevulinic acid photodynamic therapy for condyloma acuminatum of urethral meatus[J]. J Dermatolog Treat,2019, 30(7):714-717.
[13]van der Snoek E M, van Loon A M, Lammers A M, et al. Anogenital warts and human papilloma virus:knowledge, perceived nuisance and risk perception in Dutch soldiers [J]. Int J STD AIDS, 2012, 23(7):512-515.
[14]Yu X, Zheng H. Infections after photodynamic therapy in Condyloma acuminatum patients: incidence and management[J]. Environ Sci Pollut Res Int, 2018,25(14):14000-14005.
[15]Yang Y G, Zou X B, Zhao H, et al. Photodynamic therapy of condyloma acuminata in pregnant women [J]. Chin Med J (Engl), 2012, 125(16):2925-2928.
[16]景伟芳, 周娜娜, 刘雪,等. 尖锐湿疣复发患者HPV基因分型的分布情况及关系分析[J]. 中国性科学, 2018, 27(5):118-121.
[17]张恒坡, 曹冰青, 尹光文,等. 5-氨基酮戊酸光动力诊断在尖锐湿疣随访中的应用[J]. 中国艾滋病性病, 2018, 24(4): 410-412.
[18]涂平,郑和义,顾恒等.外用盐酸氨基酮戊酸光动力疗法治疗尖锐湿疣多中心随机对照研究[J].中华皮肤科杂志,2007,40(2):67-70.
[19]曹嘉力,何焱玲.5-氨基酮戊酸光动力疗法治疗尖锐湿疣的临床研究[J].实用皮肤病学杂志,2014,7(4):259-260.
[20]来文兵. 5-氨基酮戊酸光动力与液氮冷冻疗法治疗尖锐湿疣的临床效果[J]. 国际医药卫生导报, 2020, 26(21):3261-3264.
[21]Kacerovska D, Pizinger K, Kumpova M, et al. Genital warts treated by photodynamic therapy [J]. Skinmed, 2007, 6(6):295-297.