雌激素调控固有免疫细胞功能的研究进展

doi:10.3969/j.issn.1006-7795.2023.02.025

摘要/Abstract

摘要： 免疫系统存在性别二态性，女性的固有免疫反应和适应性免疫反应比男性更强，且女性对多种病原生物感染及恶性肿瘤的敏感性均较低。与此同时，女性患自身免疫性疾病的概率则更高。造成这些性别差异的重要因素之一——雌激素，在人体内发挥广泛的生物学效应。目前，雌激素已被报道可调节固有免疫细胞（包括中性粒细胞、单核细胞、巨噬细胞、自然杀伤细胞和树突状细胞）的分化、成熟、寿命和效应功能。本篇综述详细讨论了雌激素如何调节免疫细胞的正常生理功能及在各种疾病状态下的不同作用。

关键词: 雌激素, 雌激素受体, 固有免疫细胞

Abstract: The immune system has gender dimorphism. Females mount stronger innate immunity and adaptive immune response than males, and female sensitivity to multiple pathogenic infections and malignant tumors is lower. Meanwhile, women are more likely to develop autoimmune diseases. One of the important factors responsible for these sex differences, estrogen, exerts a wide range of biological effects in the human body. Currently, estrogen has been reported to regulate the differentiation, maturation, longevity, and effector function of innate immune cells, including neutrophils, monocytes and macrophages, natural killer cells, and dendritic cells. This review discusses in detail how estrogen regulates the normal physiological function of immune cells and its different roles in various disease states.

Key words: estrogen, estrogen receptors, innate immune cells

中图分类号:

R392.9

黎紫怡, 王玺, 梁璞. 雌激素调控固有免疫细胞功能的研究进展[J]. 首都医科大学学报, 2023, 44(2): 351-357.

Li Ziyi, Wang Xi, Liang Pu. Progresses on the effect of estrogen on innate immune cells[J]. Journal of Capital Medical University, 2023, 44(2): 351-357.

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