癸女贞胶囊对卵巢储备功能减退女性妊娠结局的影响

doi:10.3969/j.issn.1006-7795.2023.04.006

首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (4): 540-543.doi: 10.3969/j.issn.1006-7795.2023.04.006

• 妇科内分泌绝经与生育力保护 • 上一篇下一篇

癸女贞胶囊对卵巢储备功能减退女性妊娠结局的影响

马郡¹, 阮祥燕^1*, 许仲婷¹, 谷牧青¹, Alfred O.Mueck^1，2

1.首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科，北京 100026; 2.德国图宾根大学妇产医院内分泌与绝经中心，图宾根 D-72076

收稿日期:2023-05-09 出版日期:2023-08-21 发布日期:2023-07-26
通讯作者: 阮祥燕 E-mail:ruanxiangyan@ ccmu.edu.cn
基金资助:
北京市医院管理中心“登峰”人才培养计划项目(DFL20181401)，妇幼健康研究会中医药治疗不孕不育研究项目（2018AMCHS011）

Effect of Zi Gui Nv Zhen Capsules on pregnancy outcome in women with diminished ovarian reserve

Ma Jun¹, Ruan Xiangyan^1*, Xu Zhongting¹, Gu Muqing¹, Alfred O.Mueck^1，2

1.Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University / Beijing Maternal and Child Health Care Hospital, Beijing 100026, China; 2.Department of Women’s Health, Research Centre for Women’s Health and University Women’s Hospital of Tuebingen, University of Tuebingen, Tuebingen D-72076, Germany

Received:2023-05-09 Online:2023-08-21 Published:2023-07-26
Supported by:
This study was supported by Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401)，Association for Maternal and Child Health Studies（2018AMCHS011）.

摘要/Abstract

摘要： 目的评价资癸女贞胶囊对女性卵巢储备功能减退（diminished ovarian reserve，DOR）的疗效及其对DOR女性妊娠率和活产率的影响，为伴有DOR女性的治疗及妊娠提供新思路。方法本研究为前瞻性随机试验，在组间基线资料均衡可比的原则上，将60例患者采用数字表法随机分为观察组（n=30）和对照组（n=30）。观察组采用口服资癸女贞胶囊（每次3粒，每天3次），对照组无药物治疗。3个月后观察早卵泡期窦卵泡数（antral follicle count, AFC）、排卵日子宫内膜厚度（endometrium thickness, EMT）、卵泡期抗苗勒管激素（anti-Müllerian hormone，AMH）、妊娠率和活产率。结果基线时观察组和对照组的年龄、身高、体质量及体质量指数（body mass index，BMI）等指标差异均无统计学意义（P >0.05)；3个月后，观察组的卵泡期AMH浓度、排卵日EMT以及早卵泡期AFC均显著高于对照组（P<0.05）。跟踪随访3年后，观察组的妊娠率、活产率也显著高于对照组（P<0.05）。结论口服资癸女贞胶囊通过提高卵巢储备及女性血清AMH浓度，增加早卵泡期AFC以及EMT，有效改善女性卵巢储备功能，提高患者的妊娠率和活产率。

关键词: 资癸女贞胶囊, 卵巢储备功能减退, 妊娠率, 活产率

Abstract: Objective To evaluate the effect of Zi Gui Nv Zhen Capsules(ZGNZC) on pregnancy rate and live birth rate in women with diminished ovarian reserve(DOR), and to provide a new method for clinical treatment of DOR. Methods This study is a prospective randomized trial, 60 DOR patients (aged 20–40 years) were randomly divided into an experimental group (n=30) and a control group (n=30) with a random number table method. The experimental group received oral administration of ZGNZC (3 capsules, tid), while the control group received no medication treatment. Three months later, the data of antral follicle count (AFC) during early follicular phase, thickness of the endometrium（EMT）during ovulation day, anti-Müllerian hormone（AMH）level in the follicular phase, pregnancy rate and live birth rate were collected. Results At baseline, there was no significantly statistical difference in age, height, weight, and body mass index (BMI) between experimental group and control group (P>0.05). After three months of treatment with ZGNZC, the AMH level in the follicular phase, the EMT in ovulation day, and the AFC during early follicaler phase in the experimental group were significantly higher than those in the control group (P<0.05). After 3 years of follow-up, the pregnancy rate and the live birth rate of the experimental group were also significantly higher than those of the control group (P<0.05). Conclusions Oral administration of ZGNZC can increase the number of antral follicles, promote endometrial thickness by increasing serum AMH levels in women with DOR, improve ovarian reserve function, raise pregnancy rate and live birth rate of patients.

Key words: i Gui Nv Zhen Capsule, diminished ovarian reserve, pregnancy rate, live birth rate

中图分类号:

R711.75

马郡, 阮祥燕, 许仲婷, 谷牧青, Alfred O.Mueck. 癸女贞胶囊对卵巢储备功能减退女性妊娠结局的影响[J]. 首都医科大学学报, 2023, 44(4): 540-543.

Ma Jun, Ruan Xiangyan, Xu Zhongting, Gu Muqing, Alfred O.Mueck. Effect of Zi Gui Nv Zhen Capsules on pregnancy outcome in women with diminished ovarian reserve[J]. Journal of Capital Medical University, 2023, 44(4): 540-543.

参考文献

［1］ Bunnewell S J, Honess E R, Karia A M, et al. Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis［J］. Fertil Steril, 2020, 113(4): 818-827.e3.
［2］陈子江, 田秦杰, 乔杰, 等. 早发性卵巢功能不全的临床诊疗中国专家共识［J］. 中华妇产科杂志, 2017, 52(9): 577-581.
［3］ Busnelli A, Somigliana E, Cirillo F, et al. Is diminished ovarian reserve a risk factor for miscarriage? Results of a systematic review and meta-analysis［J］. Hum Reprod Update, 2021, 27(6): 973-988.
［4］冯建华. 中医药治疗不孕不育症经验介绍［J］. 中国医药科学, 2022, 12(9): 98-102, 130.
［5］王进进, 王宏伟, 谈勇. 补肾活血法治疗肾虚血瘀型不孕的研究进展［J］. 中国中医基础医学杂志, 2016, 22(10): 1420-1422.
［6］武红琴, 阮祥燕, 张立. 固肾安胎丸治疗子宫内膜薄性不孕症疗效的临床研究［J］. 中国中医基础医学杂志, 2015, 21(9): 1125-1127.
［7］ The ESHRE Guideline Group on POI. ESHRE guideline: management of women with premature ovarian insufficiency［J］. Hum Reprod, 2016, 31(5): 926-937.
［8］ Pfister A, Crawford N M, Steiner A Z. Association between diminished ovarian reserve and luteal phase deficiency［J］. Fertil Steril, 2019, 112(2): 378-386.
［9］ Vigneswaran K, Hamoda H. Hormone replacement therapy-current recommendations［J］. Best Pract Res Clin Obstet Gynaecol, 2022, 81: 8-21.
［10］ Liu C, Liu L H, Li N, et al. Efficacy of an yinyanghuo (Herba Epimedii Brevicornus)-Xianmao (Rhizoma Curculiginis) drug pair in a rat model of polycystic ovary syndrome［J］. J Tradit Chin Med, 2021, 41(4): 588-599.
［11］贺艳, 张乐乐, 陈旭佳, 等. 菟丝子-桑寄生改善小鼠卵巢储备功能及子宫内膜容受性［J］. 中药与临床, 2022, 13(5): 48-51.
［12］梁宇, 吴丹. 西洋参对卵巢早衰大鼠卵巢HPGDS PLA2G4A、PTGS1基因表达的影响［J］. 中国中医药科技, 2016, 23(2): 166-167.
［13］王海文, 阮祥燕, Wallwiener D, 等. 资癸女贞胶囊对子宫内膜薄性不育症妊娠结局影响的研究［J］. 首都医科大学学报, 2014, 35(4): 419-423.
［14］韩晶, 李蓉, 田莉, 等. 资癸女贞治疗子宫内膜过薄致不孕患者的临床效果［J］. 中国妇幼保健, 2017, 32(10): 2148-2149.
［15］王海文, 阮祥燕. 资癸女贞胶囊应用于子宫内膜薄性不育症的临床研究［J］. 首都医科大学学报, 2014, 35(2): 248-252.
［16］李嘉音, 李扬璐, 阮祥燕, 等. 资癸女贞胶囊治疗复发性流产的疗效观察［J］. 首都医科大学学报, 2016, 37(5): 688-692.
［17］ Xu Z T, Ruan X Y, Xu X, et al. Efficacy and safety of Zi Gui Nv Zhen capsules used in TCM for fertility preservation in patients with diminished ovarian reserve［J］. Gynecol Endocrinol, 2022, 38(1): 73-77.

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癸女贞胶囊对卵巢储备功能减退女性妊娠结局的影响

Effect of Zi Gui Nv Zhen Capsules on pregnancy outcome in women with diminished ovarian reserve

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