特纳综合征患者生育及妊娠管理的研究进展

doi:10.3969/j.issn.1006-7795.2023.04.010

摘要/Abstract

摘要： 妊娠是特纳综合征（Turner syndrome, TS）患者的关键问题，尽管4%~7%的TS患者有自然妊娠可能，但大多数女性需要借助卵母细胞捐献和生育力保护。由于卵巢功能减退通常发生在TS患者的生命早期，且妊娠可加重TS孕产妇基础心血管疾病进展或恶化的风险，如主动脉夹层或破裂等致死性并发症。因此，TS女性应该在孕前、妊娠期间和产后接受全面的心血管评估和多学科团队管理，以确保TS女性良好的生育结果。卵巢组织冻存技术是一种具有特定益处、适应证的个性化保护策略，有可能成为TS患者保护生育能力的重要工具。本文主要综述TS患者生育及妊娠管理的研究进展。

关键词: 特纳综合征, 生育力保护, 卵巢组织冻存, 妊娠风险, 孕期监测

Abstract: Pregnancy is a key problem for patients with Turner syndrome (TS). Although 4%-7% of TS patients have the possibility of natural pregnancy, most TS patients need oocyte donation and fertility protection (FP). As premature ovarian failure generally occurs early in life of women with TS, and pregnancy can increase the risk of cardiovascular abnormalities, such as aortic dissection or rupture, these patients should be counseled and evaluated as early as possible for discussion of optimal cardiovascular assessment as well as multidisciplinary team management strategies. This supervision mode is also applicable to pre-pregnancy, pregnancy, and post-pregnancy. Ovarian tissue cryopreservation is a viable option for FP in young individuals with TS. This review summarizes the research progresses of fertility and pregnancy management for women with TS.

Key words: Turner syndrome, fertility preservation, ovarian tissue cryopreservation, pregnancy risk, pregnancy monitoring

中图分类号:

R711

赵越, 阮祥燕, 谷牧青, 程姣姣, 王月姣, 金婧. 特纳综合征患者生育及妊娠管理的研究进展[J]. 首都医科大学学报, 2023, 44(4): 561-567.

Zhao Yue, Ruan Xiangyan, Gu Muqing, Cheng Jiaojiao, Wang Yuejiao, Jin Jing. Research progresses in fertility and pregnancy management in patients with Turner syndrome[J]. Journal of Capital Medical University, 2023, 44(4): 561-567.

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