关键词: 同种异体骨, 骨缺损, 骨移植, 动物模型

Abstract: Objective  To study the effects of new bone allogeneic repair on physiological and biochemical indexes of the tested animals. Methods  Male New Zealand rabbits were used to construct the animal model of bone injury, and 60 rabbits were randomly divided into experimental group, control group and blank control group. At the outer edge of proximal femur, the bone defect with a depth of about 1 mm was prepared by precision grinding mechanism with a diameter of 4 mm ball head.  In the experimental group and control group, the left femoral defect was filled with cortical bone particles, and the right femoral defect was filled with cancellous bone fragments. Animals in the blank group underwent the same operation as described above without any material filling. Blood samples were collected at 1, 4, 8 and 12 weeks after operation, and blood routine and blood biochemical examination were performed. Results  One week after surgery, the weight of animals in both groups decreased slightly, and one week later, most of the experimental animals showed an increasing trend. However, there was no significant difference in body weight change among all groups in each experimental period (P>0.05). The results of blood routine test showed that the implant had no adverse effect on the blood system and hematopoietic function of the animals. The results of biochemical examination suggest that the implantation of the test product may have some effects on the biochemical reaction and metabolism of the recipient animal, but this is still a adaptive reaction of the body and does not cause pathological effects. Conclusion  This type of allograft bone has no adverse effects on the body weight, blood routine and biochemical indexes of the tested animals, and is a safe implant repair material.

Key words: allogeneic bone, bone defect, bone graft, animal model