关键词: 抗精神病药物, 代谢综合征, 中医证型, 聚类分析, 贝叶斯网络分析

Abstract: Objective  To explore the distribution patterns of traditional Chinese medicine (TCM) syndromes in patients with metabolic syndrome caused by antipsychotic drugs.Methods  A standardized TCM syndrome survey was performed to collect diagnostic information from 160 patients diagnosed with metabolic syndrome due to antipsychotic drug use. Subsequent frequency analysis, cluster analysis, and Bayesian network analysis were carried out. The syndrome pattern distribution was ultimately determined through relevant literatures and expert opinions. Results  Five TCM syndromes were identified through frequency, cluster, and Bayesian network analyses. The most common syndrome was qi deficiency with phlegm-dampness (30%), followed by spleen deficiency with phlegm-Heat (23.75%), qi and yin deficiency Pattern (21.88%), yin deficiency with damp-heat (17.50%), and stomach fire hyperactivity pattern(6.88%).Conclusion  The pathogenesis of antipsychotics-induced metabolic syndrome involves a complex interplay of deficiency and excess factors. The primary disease is mainly located at the spleen and stomach, with involvement of the liver, kidney, and heart. Pathogenic factors include qi deficiency, yin deficiency, dampness, heat, pathogenic fire, and phlegm.

Key words: antipsychotic medications, metabolic syndrome, traditional Chinese medicine syndrome types, clustering analysis, Bayesian network analysis