冠状动脉粥样硬化性心脏病心气虚证患者自上而下和自下而上注意模式的异常

doi:10.3969/j.issn.1006-7795.2025.03.009

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (3): 455-462.doi: 10.3969/j.issn.1006-7795.2025.03.009

• 精神疾病中西医结合治疗 • 上一篇下一篇

冠状动脉粥样硬化性心脏病心气虚证患者自上而下和自下而上注意模式的异常

霍碧岫^1,2,贾竑晓^1,2*,宁艳哲^1,2,郑思思^1,2

1.首都医科大学附属北京安定医院国家精神疾病医学中心国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室,北京 100088; 2.人脑保护高精尖创新中心,首都医科大学,北京 100069

收稿日期:2025-03-04 出版日期:2025-06-21 发布日期:2025-06-25
通讯作者: 贾竑晓 E-mail:jhxlj@ ccmu.edu.cn
基金资助:
国家自然科学基金项目(82174311)，北京中医药薪火传承“新3+3”工程示范案例项目(2023-ZYSF-19)，深圳市“医疗卫生三名工程”项目（SZZYSM202411001）。

Abnormal top-down and bottom-up attention patterns in patients suffering from coronary heart disease with heart qi deficiency syndrome

Huo Bixiu^1,2, Jia Hongxiao^1,2* , Ning Yanzhe^1,2, Zheng Sisi^1,2

1. Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital, Capital Medical University,Beijing 100088,China; 2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069,China

Received:2025-03-04 Online:2025-06-21 Published:2025-06-25
Supported by:
This study was supported by National Natural Science Foundation of China (82174311), Beijing Traditional Chinese Medicine Inheritance “ New 3+3” Program Demonstration Case Project (2023-ZYSF-19), Sanming Project of Medicine in Shenzhen（SZZYSM202411001).

摘要/Abstract

摘要： 目的基于“五神藏”理论探究心气虚证冠状动脉粥样硬化性心脏病(以下简称冠心病)患者自上而下和自下而上注意模式的异常。方法 2024年7月至2024年12月广告招募心气虚证冠心病患者30例，同时按照年龄、性别、受教育年限匹配的原则招募无冠心病病史的被试30例作为对照组。2组均完成了top-down和bottom-up空间线索提示范式任务。结果与对照组相比，心气虚证冠心病患者在top-down实验中有效线索反应时（valid reaction time, vRT）更长，平均反应时差值更低（P<0.05），在bottom-up实验中短间隔有效试次反应时更长。相关性分析显示心气虚证冠心病患者组的心气虚证候积分与top-down实验指标无效线索反应时有正相关性（P<0.05），与平均反应时差值（P<0.01）和有效线索正确率有负相关性（P<0.05），与bottom-up实验指标长间隔有效试次反应时和长间隔无效试次反应时有正相关性（P<0.01）。广义线性模型分析显示对于top-down实验，非CHD被试比CHD患者vRT更短（P<0.01）、平均反应时差值更大（P<0.05）；对于bottom-up实验，非CHD被试比CHD患者短间隔有效试次反应时更短（P<0.05）。结论心气虚证冠心病患者的自上而下和自下而上注意模式改变，为五神藏“心藏神”理论提供了现代神经心理学依据。

关键词: 心气虚证, 冠状动脉粥样硬化性心脏病, 自上而下, 自下而上, 注意

Abstract: Objective To explore the abnormality of top-down and bottom-up attention patterns in patients suffering from coronary heart disease (CHD) patients with heart-qi deficiency syndrome based on the theory of “five spirits”. Methods From July 2024 to December 2024, 30 CHD patients with heart-qi deficiency syndrome were recruited, and 30 subjects without CHD as the control group according to the principle of matching age, sex and years of education. Two groups of subjects were tested with top-down and bottom-up spatial cueing paradigm. Results Compared with the control group, CHD patients with heart-qi deficiency syndrome had longer valid reaction time(vRT) and lower average reaction time difference value (△RT) in top-down test (P<0.05), and longer vSRT in bottom-up test. Correlation analysis showed that heart-qi deficiency syndrome score was positively correlated with top-down test indexes invalid reaction time (ivRT) (P<0.05)， negatively correlated with △RT (P<0.01) and valid accurany（vAC ）(P<0.05). It was positively correlated with valid long reaction time (vLRT) (P<0.01) and invalid long reaction time (ivLRT) (P<0.01). Generalized linear model analysis showed that non-CHD subjects had shorter vRT (P<0.01) and larger △RT (P<0.05) than CHD patients for top-down test. For bottom-up tests, non-CHD subjects had shorter vSRT than CHD patients (P<0.05). Conclusion The change of top-down and bottom-up attention patterns in CHD patients with heart-qi deficiency syndrome provides a modern neuropsychological basis for the theory of “heart stores spirits ”.

Key words: heart-qi deficiency syndrome, coronary heart disease, top-down, bottom-up, attention

中图分类号:

R749

霍碧岫, 贾竑晓, 宁艳哲, 郑思思. 冠状动脉粥样硬化性心脏病心气虚证患者自上而下和自下而上注意模式的异常[J]. 首都医科大学学报, 2025, 46(3): 455-462.

Huo Bixiu, Jia Hongxiao, , Ning Yanzhe, Zheng Sisi. Abnormal top-down and bottom-up attention patterns in patients suffering from coronary heart disease with heart qi deficiency syndrome[J]. Journal of Capital Medical University, 2025, 46(3): 455-462.

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冠状动脉粥样硬化性心脏病心气虚证患者自上而下和自下而上注意模式的异常

Abnormal top-down and bottom-up attention patterns in patients suffering from coronary heart disease with heart qi deficiency syndrome

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